N-15-Permethylated amino acids as efficient probes for MRI-DNP applications

Enrico Chiavazza, Alessandra Viale, Magnus Karlsson, Silvio Aime

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The synthesis, NMR properties and preliminary polarization tests on protonated and perdeuterated forms of -trimethylglutamine (NMe3Gln), -trimethylglutamate (NMe3Glu) and epsilon-trimethyllysine (NMe3Lys) are reported. The 15N-permethylated, perdeuterated amino acids display very long 15N-T1 values, ranging between 190 and 330 s, are well polarized by the dynamic nuclear polarization (DNP) procedure, yielding good polarization levels (10%), and appear to be well tolerated by cells and mice. The obtained results make perdeuterated amino acids excellent candidates for innovative DNP 15N-MRI applications such as perfusion or targeting studies. Copyright (c) 2013 John Wiley & Sons, Ltd.
Original languageEnglish
JournalContrast Media & Molecular Imaging
Volume8
Issue number5
Pages (from-to)417-421
ISSN1555-4309
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Amino Acids
  • Animals
  • Cell Tracking
  • Magnetic Resonance Imaging
  • Mice
  • Nitrogen Isotopes
  • Staining and Labeling
  • Radiology, Nuclear Medicine and Imaging
  • Medicine (all)
  • 15N
  • DNP
  • Hyperpolarized probe
  • Perfusion agent
  • Spin-lattice relaxation time
  • alpha trimethylglutamate
  • alpha trimethylglutamine
  • contrast medium
  • epsilon trimethyllysine
  • unclassified drug
  • amino acid
  • nitrogen
  • animal cell
  • animal experiment
  • article
  • controlled study
  • drug synthesis
  • male
  • mouse
  • nonhuman
  • nuclear magnetic resonance imaging
  • polarization
  • priority journal
  • proton nuclear magnetic resonance
  • proton transport
  • rat
  • relaxation time
  • animal
  • cell tracking
  • chemistry
  • staining
  • RADIOLOGY,
  • HYPERPOLARIZED C-13
  • MAGNETIC-RESONANCE
  • CONTRAST AGENTS
  • Y-89
  • PERFUSION
  • NMR
  • hyperpolarized probe
  • N-15
  • perfusion agent
  • spin-lattice relaxation time

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