Myristoylation of foot-and-mouth-disease virus capsid protein precursors is independent of other viral-proteins and occurs in both mammalian and insect cells

Graham Belsham, C. C. Abrams, A. M. Q. King, J. Roosien, J. M. Vlak

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The myristoylation of the foot-and-mouth disease virus (FMDV) capsid precursor P1-2A and its amino-terminal cleavage product 1AB, expressed from subgenomic cDNA, has been analysed. The modification reaction is independent of other FMDV proteins and occurs in both mammalian and insect cells. Blocking of the myristoylation site does not prevent efficient processing of the FMDV capsid precursor. A cDNA cassette in which the leader protease sequence is substituted by an ATG codon produces myristoylated 1AB, indicating correct removal of the novel N-terminal methionine residue.
Original languageEnglish
JournalJournal of General Virology
Volume72
Issue numberPart 3
Pages (from-to)747-751
ISSN0022-1317
DOIs
Publication statusPublished - 1991
Externally publishedYes

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