Myocardial performance is reduced immediately prior to ventricular ectopy

Research output: Contribution to journalJournal article – Annual report year: 2011Researchpeer-review

  • Author: Bloch Thomsen, Poul Erik

    Copenhagen University Hospital

  • Author: Hansen, Thomas Fritz

    Copenhagen University Hospital

  • Author: Jons, Christian

    University of Rochester School of Medicine and Dentistry

  • Author: Olsen, Thue

    Copenhagen University Hospital

  • Author: Johannessen, Arne

    Copenhagen University Hospital

  • Author: Særmark, Knud

    Department of Physics, Technical University of Denmark

  • Author: McNitt, Scott

    University of Rochester School of Medicine and Dentistry

  • Author: Haigney, Mark

    University of Maryland

  • Author: Sogaard, Peter

    Copenhagen University Hospital

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Background: We recently demonstrated local voltage potentials indicating conduction impairment and block in the sinus beats preceding ventricular premature beats (VPBs) originating in the ventricular outflow tracts. Objective: The purpose of this study was to test the hypothesis that impairment of impulse conduction would also lead to changes in the contractile performance of sinus beats preceding ventricular ectopy using Tissue Doppler echocardiography. Methods: Twenty-three consecutive patients with VPBs were examined in the apical 4-chamber view with a frame rate of 150 Hz (GE VIVID VII). Eleven patients had no structural heart disease, 5 had dilated cardiomyopathy, 4 had ischemic heart disease, 2 had arrhythmogenic right ventricular dysplasia, and 1 had aortic stenosis. The ectopy originated in the ventricular outflow tracts in 15 patients and in the left ventricle 8. Eleven of the patients underwent radiofrequency ablation of the VPBs. Results: Tissue Doppler imaging demonstrated a highly statistically significant decrease in myocardial performance in the last sinus beat before the VPB compared to earlier sinus beats. Thus, ejection time (time to peak end-systolic contraction) and peak systolic velocity shortened significantly (P
Original languageEnglish
JournalHeart Rhythm
Volume9
Issue number1
Pages (from-to)86-90
ISSN1547-5271
DOIs
Publication statusPublished - 2012
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Cardiomyopathy, Conduction impairment, Tissue Doppler imaging, Ventricular premature beats
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