Myocardial performance is reduced immediately prior to ventricular ectopy

Poul Erik Bloch Thomsen, Thomas Fritz Hansen, Christian Jons, Thue Olsen, Arne Johannessen, Knud Særmark, Scott McNitt, Mark Haigney, Peter Sogaard

Research output: Contribution to journalJournal articleResearchpeer-review


Background: We recently demonstrated local voltage potentials indicating conduction impairment and block in the sinus beats preceding ventricular premature beats (VPBs) originating in the ventricular outflow tracts. Objective: The purpose of this study was to test the hypothesis that impairment of impulse conduction would also lead to changes in the contractile performance of sinus beats preceding ventricular ectopy using Tissue Doppler echocardiography. Methods: Twenty-three consecutive patients with VPBs were examined in the apical 4-chamber view with a frame rate of 150 Hz (GE VIVID VII). Eleven patients had no structural heart disease, 5 had dilated cardiomyopathy, 4 had ischemic heart disease, 2 had arrhythmogenic right ventricular dysplasia, and 1 had aortic stenosis. The ectopy originated in the ventricular outflow tracts in 15 patients and in the left ventricle 8. Eleven of the patients underwent radiofrequency ablation of the VPBs. Results: Tissue Doppler imaging demonstrated a highly statistically significant decrease in myocardial performance in the last sinus beat before the VPB compared to earlier sinus beats. Thus, ejection time (time to peak end-systolic contraction) and peak systolic velocity shortened significantly (P
Original languageEnglish
JournalHeart Rhythm
Issue number1
Pages (from-to)86-90
Publication statusPublished - 2012


  • Cardiomyopathy
  • Conduction impairment
  • Tissue Doppler imaging
  • Ventricular premature beats


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