Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes

I. Ventre, A.L. Goodman, I. Vallet-Gely, P. Vasseur, C. Soscia, Søren Molin, S. Bleves, A. Lazdunski, S. Lory, A. Filloux

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The opportunistic pathogen Pseudomonas aeruginosa is responsible for a wide range of acute and chronic infections. The transition to chronic infections is accompanied by physiological changes in the bacteria favoring formation of biofilm communities. Here we report the identification of LadS, a hybrid sensor kinase that controls the reciprocal expression of genes for type III secretion and biofilm-promoting polysaccharicles. Domain organization of LadS and the range of LadS-controlled genes suggest that it counteracts the activities of another sensor kinase, RetS. These two pathways converge by controlling the transcription of a small regulatory RNA, RsmZ. This work identifies a previously undescribed signal transduction network in which the activities of signal-receiving sensor kinases LadS, RetS, and GacS regulate expression of virulence genes associated with acute or chronic infection by transcriptional and posttranscriptional mechanisms.
    Original languageEnglish
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume103
    Issue number1
    Pages (from-to)171-176
    ISSN0027-8424
    Publication statusPublished - 2006

    Keywords

    • two-component system
    • small RNA
    • biofilm
    • type III secretion
    • pel genes

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