Multiphase compartment modelling and systems identification of a U-loop reactor for continuous single cell protein production

Johan le Nepvou de Carfort; Tiago Pinto; Ulrich Krühne

doi:10.1016/B978-0-443-28824-1.50307-0

Multiphase compartment modelling and systems identification of a U-loop reactor for continuous single cell protein production

Johan le Nepvou de Carfort, Tiago Pinto, Ulrich Krühne^*

^*Corresponding author for this work

Unibio A/S

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Abstract

In this study, a multiphase compartment model for U-loop bioreactors is proposed and applied to a 5.5 [m3] pilot scale U-loop. The developed compartment model that includes the material balance of multiple compounds in the gas and liquid phases as well as interfacial mass transfer is coupled with the microbial biokinetics to simulate the fermentation process. The model inputs and outputs are identified in terms of control systems, and the model is linearized around industrially relevant operating conditions. The linearized system is identified in terms of relative gain and a linear state-space model is fitted.

Original language	English
Title of host publication	Proceedings of the 34th European Symposium on Computer Aided Process Engineering
Editors	Flavio Manenti, Gintaras V. Reklaitis
Volume	53
Publisher	Elsevier
Publication date	2024
Pages	1837-1842
DOIs	https://doi.org/10.1016/B978-0-443-28824-1.50307-0
Publication status	Published - 2024
Event	34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering - Florence, Italy Duration: 2 Jun 2024 → 6 Jun 2024

Conference

Conference	34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering
Country/Territory	Italy
City	Florence
Period	02/06/2024 → 06/06/2024

Keywords

Compartment model
Multiphase
Bioreactor
Process control

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10.1016/B978-0-443-28824-1.50307-0

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de Carfort, J. L. N., Pinto, T., & Krühne, U. (2024). Multiphase compartment modelling and systems identification of a U-loop reactor for continuous single cell protein production. In F. Manenti, & G. V. Reklaitis (Eds.), Proceedings of the 34th European Symposium on Computer Aided Process Engineering (Vol. 53, pp. 1837-1842). Elsevier. https://doi.org/10.1016/B978-0-443-28824-1.50307-0

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title = "Multiphase compartment modelling and systems identification of a U-loop reactor for continuous single cell protein production",

abstract = "In this study, a multiphase compartment model for U-loop bioreactors is proposed and applied to a 5.5 [m3] pilot scale U-loop. The developed compartment model that includes the material balance of multiple compounds in the gas and liquid phases as well as interfacial mass transfer is coupled with the microbial biokinetics to simulate the fermentation process. The model inputs and outputs are identified in terms of control systems, and the model is linearized around industrially relevant operating conditions. The linearized system is identified in terms of relative gain and a linear state-space model is fitted.",

keywords = "Compartment model, Multiphase, Bioreactor, Process control",

author = "{de Carfort}, {Johan le Nepvou} and Tiago Pinto and Ulrich Kr{\"u}hne",

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doi = "10.1016/B978-0-443-28824-1.50307-0",

language = "English",

volume = "53",

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booktitle = "Proceedings of the 34th European Symposium on Computer Aided Process Engineering",

publisher = "Elsevier",

address = "United Kingdom",

note = "34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering, ESCAPE34 - PSE24 ; Conference date: 02-06-2024 Through 06-06-2024",

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de Carfort, JLN, Pinto, T & Krühne, U 2024, Multiphase compartment modelling and systems identification of a U-loop reactor for continuous single cell protein production. in F Manenti & G V. Reklaitis (eds), Proceedings of the 34th European Symposium on Computer Aided Process Engineering. vol. 53, Elsevier, pp. 1837-1842, 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering, Florence, Italy, 02/06/2024. https://doi.org/10.1016/B978-0-443-28824-1.50307-0

Multiphase compartment modelling and systems identification of a U-loop reactor for continuous single cell protein production. / de Carfort, Johan le Nepvou; Pinto, Tiago; Krühne, Ulrich.
Proceedings of the 34th European Symposium on Computer Aided Process Engineering. ed. / Flavio Manenti; Gintaras V. Reklaitis. Vol. 53 Elsevier, 2024. p. 1837-1842.

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

TY - GEN

T1 - Multiphase compartment modelling and systems identification of a U-loop reactor for continuous single cell protein production

AU - de Carfort, Johan le Nepvou

AU - Pinto, Tiago

AU - Krühne, Ulrich

PY - 2024

Y1 - 2024

N2 - In this study, a multiphase compartment model for U-loop bioreactors is proposed and applied to a 5.5 [m3] pilot scale U-loop. The developed compartment model that includes the material balance of multiple compounds in the gas and liquid phases as well as interfacial mass transfer is coupled with the microbial biokinetics to simulate the fermentation process. The model inputs and outputs are identified in terms of control systems, and the model is linearized around industrially relevant operating conditions. The linearized system is identified in terms of relative gain and a linear state-space model is fitted.

AB - In this study, a multiphase compartment model for U-loop bioreactors is proposed and applied to a 5.5 [m3] pilot scale U-loop. The developed compartment model that includes the material balance of multiple compounds in the gas and liquid phases as well as interfacial mass transfer is coupled with the microbial biokinetics to simulate the fermentation process. The model inputs and outputs are identified in terms of control systems, and the model is linearized around industrially relevant operating conditions. The linearized system is identified in terms of relative gain and a linear state-space model is fitted.

KW - Compartment model

KW - Multiphase

KW - Bioreactor

KW - Process control

U2 - 10.1016/B978-0-443-28824-1.50307-0

DO - 10.1016/B978-0-443-28824-1.50307-0

M3 - Article in proceedings

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EP - 1842

BT - Proceedings of the 34th European Symposium on Computer Aided Process Engineering

A2 - Manenti, Flavio

A2 - V. Reklaitis, Gintaras

PB - Elsevier

T2 - 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering

Y2 - 2 June 2024 through 6 June 2024

ER -

Multiphase compartment modelling and systems identification of a U-loop reactor for continuous single cell protein production

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