Multimodality functional imaging of spontaneous canine tumors using 64CU-ATSM and 18FDG PET/CT and dynamic contrast enhanced perfusion CT

Anders Elias Hansen, Annemarie T. Kristensen, Ian Law, Fintan J. McEvoy, Andreas Kjær, Svend A. Engelholm

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Purpose

To compare the distribution and uptake of the hypoxia tracer 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu-ATSM) PET/CT, FDG PET/CT and dynamic contrast enhanced perfusion CT (DCE-pCT) in spontaneous canine tumors. In addition 64Cu-ATSM distribution over time was evaluated.

Methods and materials

Nine spontaneous cancer-bearing dogs were prospectively enrolled. FDG (1 h pi.) and 64Cu-ATSM (3 and 24 h pi.) PET/CT were performed over three consecutive days. DCE-pCT was performed on day 2. Tumor uptake of FDG and 64Cu-ATSM was assessed semi-quantitatively and the distribution of FDG, 64Cu-ATSM and CT perfusion parameters correlated.

Results

64Cu-ATSM distribution on scans performed 24 h apart displayed moderate to strong correlation; however, temporal changes were observed. The spatial distribution pattern of 64Cu-ATSM between scans was moderately to strongly positively correlated to FDG, whereas the correlation of CT perfusion parameters to FDG and to 64Cu-ATSM yielded more varying results.

Conclusions

64Cu-ATSM uptake was positively correlated to FDG. 64Cu-ATSM was found to be relatively stable between PET scans performed at different time points, important temporal changes were however observed in hypo-perfused regions. These findings potentially indicate that prolonged uptake periods for 64Cu-ATSM imaging may be needed. Although a moderate to strong correlation between 64Cu-ATSM and FDG PET/CT is observed, the two tracers provide different biological information with an overlapping spatial distribution.

Original languageEnglish
JournalRadiotherapy and Oncology
Volume102
Issue number3
Pages (from-to)424-428
Number of pages5
ISSN0167-8140
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Animals
  • Contrast Media
  • Copper Radioisotopes
  • Dog Diseases
  • Dogs
  • Fluorodeoxyglucose F18
  • Neoplasms
  • Organometallic Compounds
  • Perfusion Imaging
  • Positron-Emission Tomography and Computed Tomography
  • Radiographic Image Enhancement
  • Radiopharmaceuticals
  • Thiosemicarbazones

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