TY - JOUR
T1 - Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017
AU - Terkelsen, David
AU - Tolstrup, Jacob
AU - Johnsen, Camilla Hundahl
AU - Lund, Ole
AU - Larsen, Helle Kiellberg
AU - Worning, Peder
AU - Unemo, Magnus
AU - Westh, Henrik
N1 - This work is licensed under a Creative Commons Attribution 4.0 International License.
PY - 2017
Y1 - 2017
N2 - We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.
AB - We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.
U2 - 10.2807/1560-7917.ES.2017.22.42.17-00659
DO - 10.2807/1560-7917.ES.2017.22.42.17-00659
M3 - Journal article
C2 - 29067905
SN - 1025-496X
VL - 22
JO - Eurosurveillance (Print)
JF - Eurosurveillance (Print)
IS - 42
M1 - 17-00659
ER -