Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising

Rie Beck Hansen; Jeremy W. Gordon; Peter J. Shin; Zihan Zhu; Daniele Mammoli; Pamela N. Munster; Rahul Aggarwal; Michael A. Ohliger; Peder EZ Larson; Lars G.  Hanson; Jan Henrik Ardenkjær-Larsen; Daniel B. Vigneron

Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising

Rie Beck Hansen, Jeremy W. Gordon, Peter J. Shin, Zihan Zhu, Daniele Mammoli , Pamela N. Munster, Rahul Aggarwal, Michael A. Ohliger, Peder EZ Larson, Lars G. Hanson, Jan Henrik Ardenkjær-Larsen, Daniel B. Vigneron

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Abstract

Hyperpolarized 13C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human 13C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness, and is applied with automatic threshold estimation. In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.

Original language	English
Publication date	2018
Number of pages	3
Publication status	Published - 2018
Event	Joint Annual Meeting ISMRM-ESMRMB 2018 - Paris Expo Porte de Versailles, Paris, France Duration: 16 Jun 2018 → 21 Jun 2018 https://www.ismrm.org/18m/

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Conference	Joint Annual Meeting ISMRM-ESMRMB 2018
Location	Paris Expo Porte de Versailles
Country/Territory	France
City	Paris
Period	16/06/2018 → 21/06/2018
Internet address	https://www.ismrm.org/18m/

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Hansen, R. B., Gordon, J. W., Shin, P. J., Zhu, Z., Mammoli , D., Munster, P. N., Aggarwal, R., Ohliger, M. A., Larson, P. EZ., Hanson, L. G., Ardenkjær-Larsen, J. H., & Vigneron, D. B. (2018). Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising. Abstract from Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.

@conference{816ef6e9e20b4127bad0e87aba28cf1b,

title = "Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising",

abstract = "Hyperpolarized 13C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human 13C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness, and is applied with automatic threshold estimation. In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.",

author = "Hansen, {Rie Beck} and Gordon, {Jeremy W.} and Shin, {Peter J.} and Zihan Zhu and Daniele Mammoli and Munster, {Pamela N.} and Rahul Aggarwal and Ohliger, {Michael A.} and Larson, {Peder EZ} and Hanson, {Lars G.} and Ardenkj{\ae}r-Larsen, {Jan Henrik} and Vigneron, {Daniel B.}",

year = "2018",

language = "English",

note = "Joint Annual Meeting ISMRM-ESMRMB 2018 ; Conference date: 16-06-2018 Through 21-06-2018",

url = "https://www.ismrm.org/18m/",

}

Hansen, RB, Gordon, JW, Shin, PJ, Zhu, Z, Mammoli , D, Munster, PN, Aggarwal, R, Ohliger, MA, Larson, PEZ, Hanson, LG , Ardenkjær-Larsen, JH & Vigneron, DB 2018, 'Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising', Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France, 16/06/2018 - 21/06/2018.

Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising. / Hansen, Rie Beck; Gordon, Jeremy W.; Shin, Peter J. et al.
2018. Abstract from Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

TY - ABST

T1 - Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising

AU - Hansen, Rie Beck

AU - Gordon, Jeremy W.

AU - Shin, Peter J.

AU - Zhu, Zihan

AU - Mammoli , Daniele

AU - Munster, Pamela N.

AU - Aggarwal, Rahul

AU - Ohliger, Michael A.

AU - Larson, Peder EZ

AU - Hanson, Lars G.

AU - Ardenkjær-Larsen, Jan Henrik

AU - Vigneron, Daniel B.

PY - 2018

Y1 - 2018

N2 - Hyperpolarized 13C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human 13C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness, and is applied with automatic threshold estimation. In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.

AB - Hyperpolarized 13C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human 13C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness, and is applied with automatic threshold estimation. In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.

M3 - Conference abstract for conference

T2 - Joint Annual Meeting ISMRM-ESMRMB 2018

Y2 - 16 June 2018 through 21 June 2018

ER -

Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising

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