Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising

Rie Beck Hansen, Jeremy W. Gordon, Peter J. Shin, Zihan Zhu, Daniele Mammoli , Pamela N. Munster, Rahul Aggarwal, Michael A. Ohliger, Peder EZ Larson, Lars G. Hanson, Jan Henrik Ardenkjær-Larsen, Daniel B. Vigneron

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

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Abstract

Hyperpolarized 13C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human 13C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness, and is applied with automatic threshold estimation. In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.
Original languageEnglish
Publication date2018
Number of pages3
Publication statusPublished - 2018
EventJoint Annual Meeting ISMRM-ESMRMB 2018 - Paris Expo Porte de Versailles, Paris, France
Duration: 16 Jun 201821 Jun 2018
https://www.ismrm.org/18m/

Conference

ConferenceJoint Annual Meeting ISMRM-ESMRMB 2018
LocationParis Expo Porte de Versailles
CountryFrance
CityParis
Period16/06/201821/06/2018
Internet address

Cite this

Hansen, R. B., Gordon, J. W., Shin, P. J., Zhu, Z., Mammoli , D., Munster, P. N., ... Vigneron, D. B. (2018). Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising. Abstract from Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.
Hansen, Rie Beck ; Gordon, Jeremy W. ; Shin, Peter J. ; Zhu, Zihan ; Mammoli , Daniele ; Munster, Pamela N. ; Aggarwal, Rahul ; Ohliger, Michael A. ; Larson, Peder EZ ; Hanson, Lars G. ; Ardenkjær-Larsen, Jan Henrik ; Vigneron, Daniel B. / Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising. Abstract from Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.3 p.
@conference{816ef6e9e20b4127bad0e87aba28cf1b,
title = "Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising",
abstract = "Hyperpolarized 13C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human 13C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness, and is applied with automatic threshold estimation. In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.",
author = "Hansen, {Rie Beck} and Gordon, {Jeremy W.} and Shin, {Peter J.} and Zihan Zhu and Daniele Mammoli and Munster, {Pamela N.} and Rahul Aggarwal and Ohliger, {Michael A.} and Larson, {Peder EZ} and Hanson, {Lars G.} and Ardenkj{\ae}r-Larsen, {Jan Henrik} and Vigneron, {Daniel B.}",
year = "2018",
language = "English",
note = "Joint Annual Meeting ISMRM-ESMRMB 2018 ; Conference date: 16-06-2018 Through 21-06-2018",
url = "https://www.ismrm.org/18m/",

}

Hansen, RB, Gordon, JW, Shin, PJ, Zhu, Z, Mammoli , D, Munster, PN, Aggarwal, R, Ohliger, MA, Larson, PEZ, Hanson, LG, Ardenkjær-Larsen, JH & Vigneron, DB 2018, 'Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising' Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France, 16/06/2018 - 21/06/2018, .

Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising. / Hansen, Rie Beck; Gordon, Jeremy W.; Shin, Peter J.; Zhu, Zihan; Mammoli , Daniele; Munster, Pamela N.; Aggarwal, Rahul; Ohliger, Michael A.; Larson, Peder EZ; Hanson, Lars G. ; Ardenkjær-Larsen, Jan Henrik; Vigneron, Daniel B.

2018. Abstract from Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

TY - ABST

T1 - Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising

AU - Hansen, Rie Beck

AU - Gordon, Jeremy W.

AU - Shin, Peter J.

AU - Zhu, Zihan

AU - Mammoli , Daniele

AU - Munster, Pamela N.

AU - Aggarwal, Rahul

AU - Ohliger, Michael A.

AU - Larson, Peder EZ

AU - Hanson, Lars G.

AU - Ardenkjær-Larsen, Jan Henrik

AU - Vigneron, Daniel B.

PY - 2018

Y1 - 2018

N2 - Hyperpolarized 13C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human 13C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness, and is applied with automatic threshold estimation. In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.

AB - Hyperpolarized 13C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human 13C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness, and is applied with automatic threshold estimation. In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.

M3 - Conference abstract for conference

ER -

Hansen RB, Gordon JW, Shin PJ, Zhu Z, Mammoli D, Munster PN et al. Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising. 2018. Abstract from Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.