Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising

Rie Beck Hansen, Jeremy W. Gordon, Peter J. Shin, Zihan Zhu, Daniele Mammoli , Pamela N. Munster, Rahul Aggarwal, Michael A. Ohliger, Peder EZ Larson, Lars G. Hanson, Jan Henrik Ardenkjær-Larsen, Daniel B. Vigneron

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Hyperpolarized 13C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human 13C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness, and is applied with automatic threshold estimation. In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.
Original languageEnglish
Publication date2018
Number of pages3
Publication statusPublished - 2018
EventJoint Annual Meeting ISMRM-ESMRMB 2018 - Paris Expo Porte de Versailles, Paris, France
Duration: 16 Jun 201821 Jun 2018


ConferenceJoint Annual Meeting ISMRM-ESMRMB 2018
LocationParis Expo Porte de Versailles
Internet address

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