Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising

Rie Beck Hansen, Jeremy W. Gordon, Peter J. Shin, Zihan Zhu, Daniele Mammoli , Pamela N. Munster, Rahul Aggarwal, Michael A. Ohliger, Peder EZ Larson, Lars G. Hanson, Jan Henrik Ardenkjær-Larsen, Daniel B. Vigneron

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    Abstract

    Hyperpolarized 13C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human 13C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness, and is applied with automatic threshold estimation. In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.
    Original languageEnglish
    Publication date2018
    Number of pages3
    Publication statusPublished - 2018
    EventJoint Annual Meeting ISMRM-ESMRMB 2018 - Paris Expo Porte de Versailles, Paris, France
    Duration: 16 Jun 201821 Jun 2018
    https://www.ismrm.org/18m/

    Conference

    ConferenceJoint Annual Meeting ISMRM-ESMRMB 2018
    LocationParis Expo Porte de Versailles
    Country/TerritoryFrance
    CityParis
    Period16/06/201821/06/2018
    Internet address

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