Multi-scale Exploration of the Technical, Economic, and Environmental Dimensions of Bio-based Chemical Production

Kai Zhuang, Markus Herrgard

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review


In recent years, bio-based chemicals have gained traction as a sustainable alternative topetrochemicals. In order to maximize the impacts of researches and investments, there is a need to focus on the most promising combinations of feedstocks, biochemical products, and bioprocesses. To address this issue, we developed a multiscale framework that integrates modeling approaches across scales of cellular metabolism, bioreactor, bioprocess, and economy/ecosystem, and is able to simultaneously assess biological, technological, economic and environmental feasibility of different production scenarios. Using our framework, we assess the production of two major polymer precursors (1,3-propanediol and 3-hydroxypropionic acid) from two biomass feedstocks (corn-based glucose and soy-based glycerol) using two host organisms (E.coli and S. cerevisiae). We explore the sustainability and economic impacts of a variety of policies and practices (e.g. land-usage, energy source mixture, CO2 emission cap), as well as trade offs between different objectives (e.g. profits for different sectors, emission minimization) for key stakeholders involved in the biochemical value chain (agriculture, energy, and biotechnology sectors).
Original languageEnglish
Title of host publicationAbstract Book - DTU Sustain Conference 2014
Number of pages1
Place of PublicationKgs. Lyngby
PublisherTechnical University of Denmark
Publication date2014
Publication statusPublished - 2014
EventDTU Sustain Conference 2014 - Technical University of Denmark, Lyngby, Denmark
Duration: 17 Dec 201417 Dec 2014


ConferenceDTU Sustain Conference 2014
LocationTechnical University of Denmark
Internet address


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