Multi-omic profiling of EPO producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Daniel Ley, Ali Kazemi Seresht, Mikael Engmark, Olivera Magdenoska, Kristian Fog Nielsen, Helene Faustrup Kildegaard, Mikael Rørdam Andersen

Research output: Contribution to conference › Poster › Research › peer-review

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Abstract

Heterologous protein production in CHO cells imposes a burden on the host cell metabolism and impact cellular physiology on a global scale. In this work, a multi-omics approach was applied to characterize the physiological impact of erythropoietin production, and discover production bottlenecks, in a panel of CHO-K1 cells in batch and chemostat culture.
Original languageEnglish
Publication date2016
Number of pages1
Publication statusPublished - 2016
EventCell Culture Engineering XV - La Quinta, United States
Duration: 8 May 2016 → 13 May 2016

Conference

ConferenceCell Culture Engineering XV
Country/TerritoryUnited States
CityLa Quinta
Period08/05/2016 → 13/05/2016

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    • 1 Participating in or organising a conference

    • Cell Culture Engineering XV

      Ley, D. (Participant)

      8 May 2016 → 13 May 2016

      Activity: Attending an event › Participating in or organising a conference

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