Multi-dimensional microstructural imaging offers novel in vivo insights into brain pathology: an application to multiple sclerosis

Kasper Winther Andersen; Samo Lasic; Henrik Lundell; Markus  Nilsson; Daniel Topgaard; Filip Szczepankiewicz; Lars G.  Hanson; Hartwig Siebner; Morten Blinkenberg; Tim Dyrby

Multi-dimensional microstructural imaging offers novel in vivo insights into brain pathology: an application to multiple sclerosis

Kasper Winther Andersen, Samo Lasic, Henrik Lundell, Markus Nilsson, Daniel Topgaard, Filip Szczepankiewicz, Lars G. Hanson, Hartwig Siebner, Morten Blinkenberg, Tim Dyrby

Department of Electrical Engineering

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

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Abstract

Magnetic resonance imaging is today the most versatile imaging method for characterization of multiple sclerosis (MS) in vivo, but clinical examinations lack sensitivity to capture changes in the tissue microstructure. Using a multi-dimensional microstructural imaging approach, we demonstrate how it is possible to obtain more specific and broader microstructural insights about the underlying pathology of MS. For this we use a comprehensive battery of conventional and novel diffusion weighted imaging and quantitative MRI sequences each capable of explaining different and complementary microstructural properties. This allows us to explore the underlying pathology of MS, which is normally only accessible with histology.

Original language	English
Publication date	2018
Number of pages	3
Publication status	Published - 2018
Event	Joint Annual Meeting ISMRM-ESMRMB 2018 - Paris Expo Porte de Versailles, Paris, France Duration: 16 Jun 2018 → 21 Jun 2018 https://www.ismrm.org/18m/

Conference

Conference	Joint Annual Meeting ISMRM-ESMRMB 2018
Location	Paris Expo Porte de Versailles
Country	France
City	Paris
Period	16/06/2018 → 21/06/2018
Internet address	https://www.ismrm.org/18m/

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Andersen, Kasper Winther ; Lasic, Samo ; Lundell, Henrik ; Nilsson, Markus ; Topgaard, Daniel ; Szczepankiewicz, Filip ; Hanson, Lars G. ; Siebner, Hartwig ; Blinkenberg, Morten ; Dyrby, Tim. / Multi-dimensional microstructural imaging offers novel in vivo insights into brain pathology: an application to multiple sclerosis. Abstract from Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.3 p.

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title = "Multi-dimensional microstructural imaging offers novel in vivo insights into brain pathology: an application to multiple sclerosis",

abstract = "Magnetic resonance imaging is today the most versatile imaging method for characterization of multiple sclerosis (MS) in vivo, but clinical examinations lack sensitivity to capture changes in the tissue microstructure. Using a multi-dimensional microstructural imaging approach, we demonstrate how it is possible to obtain more specific and broader microstructural insights about the underlying pathology of MS. For this we use a comprehensive battery of conventional and novel diffusion weighted imaging and quantitative MRI sequences each capable of explaining different and complementary microstructural properties. This allows us to explore the underlying pathology of MS, which is normally only accessible with histology.",

author = "Andersen, {Kasper Winther} and Samo Lasic and Henrik Lundell and Markus Nilsson and Daniel Topgaard and Filip Szczepankiewicz and Hanson, {Lars G.} and Hartwig Siebner and Morten Blinkenberg and Tim Dyrby",

year = "2018",

language = "English",

note = "Joint Annual Meeting ISMRM-ESMRMB 2018 ; Conference date: 16-06-2018 Through 21-06-2018",

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Multi-dimensional microstructural imaging offers novel in vivo insights into brain pathology: an application to multiple sclerosis. / Andersen, Kasper Winther; Lasic, Samo; Lundell, Henrik; Nilsson, Markus ; Topgaard, Daniel; Szczepankiewicz, Filip; Hanson, Lars G. ; Siebner, Hartwig; Blinkenberg, Morten; Dyrby, Tim.

2018. Abstract from Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

TY - ABST

T1 - Multi-dimensional microstructural imaging offers novel in vivo insights into brain pathology: an application to multiple sclerosis

AU - Andersen, Kasper Winther

AU - Lasic, Samo

AU - Lundell, Henrik

AU - Nilsson, Markus

AU - Topgaard, Daniel

AU - Szczepankiewicz, Filip

AU - Hanson, Lars G.

AU - Siebner, Hartwig

AU - Blinkenberg, Morten

AU - Dyrby, Tim

PY - 2018

Y1 - 2018

N2 - Magnetic resonance imaging is today the most versatile imaging method for characterization of multiple sclerosis (MS) in vivo, but clinical examinations lack sensitivity to capture changes in the tissue microstructure. Using a multi-dimensional microstructural imaging approach, we demonstrate how it is possible to obtain more specific and broader microstructural insights about the underlying pathology of MS. For this we use a comprehensive battery of conventional and novel diffusion weighted imaging and quantitative MRI sequences each capable of explaining different and complementary microstructural properties. This allows us to explore the underlying pathology of MS, which is normally only accessible with histology.

AB - Magnetic resonance imaging is today the most versatile imaging method for characterization of multiple sclerosis (MS) in vivo, but clinical examinations lack sensitivity to capture changes in the tissue microstructure. Using a multi-dimensional microstructural imaging approach, we demonstrate how it is possible to obtain more specific and broader microstructural insights about the underlying pathology of MS. For this we use a comprehensive battery of conventional and novel diffusion weighted imaging and quantitative MRI sequences each capable of explaining different and complementary microstructural properties. This allows us to explore the underlying pathology of MS, which is normally only accessible with histology.

M3 - Conference abstract for conference

T2 - Joint Annual Meeting ISMRM-ESMRMB 2018

Y2 - 16 June 2018 through 21 June 2018

ER -