Multi-dimensional microstructural imaging offers novel in vivo insights into brain pathology: an application to multiple sclerosis

Kasper Winther Andersen, Samo Lasic, Henrik Lundell, Markus Nilsson, Daniel Topgaard, Filip Szczepankiewicz, Lars G. Hanson, Hartwig Siebner, Morten Blinkenberg, Tim Dyrby

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Abstract

Magnetic resonance imaging is today the most versatile imaging method for characterization of multiple sclerosis (MS) in vivo, but clinical examinations lack sensitivity to capture changes in the tissue microstructure. Using a multi-dimensional microstructural imaging approach, we demonstrate how it is possible to obtain more specific and broader microstructural insights about the underlying pathology of MS. For this we use a comprehensive battery of conventional and novel diffusion weighted imaging and quantitative MRI sequences each capable of explaining different and complementary microstructural properties. This allows us to explore the underlying pathology of MS, which is normally only accessible with histology.
Original languageEnglish
Publication date2018
Number of pages3
Publication statusPublished - 2018
EventJoint Annual Meeting ISMRM-ESMRMB 2018 - Paris Expo Porte de Versailles, Paris, France
Duration: 16 Jun 201821 Jun 2018
https://www.ismrm.org/18m/

Conference

ConferenceJoint Annual Meeting ISMRM-ESMRMB 2018
LocationParis Expo Porte de Versailles
CountryFrance
CityParis
Period16/06/201821/06/2018
Internet address

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