Mr-method for the in vivo measurement of temperature or ph-value by means of a hyperpolarised contrast agent

Oskar Axelsson (Inventor), Jan Henrik Ardenkjær-Larsen (Inventor), Sven Månsson (Inventor), Stefan Petersson (Inventor), Ib Leunbach (Inventor)

Research output: Patent

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Abstract

The present invention provides a method of MR investigation of a sample, said method comprising: (i) nuclear spin polarising a high T1 MR imaging agent which contains in its molecular structure at least two hyperpolarisable nuclei within the same molecule, the frequency difference between the two resonance lines from said nuclei, deltav, being dependent upon either the temperature or the pH of said sample; (ii) administering the nuclear spin polarised MR imaging agent to said sample; (iii) exposing said sample to a radiation at a frequency selected to excite nuclear spin transitions in said MR imaging agent; and (iv) detecting and manipulating magnetic resonance signals from said sample using a single-shot RARE acquisition sequence with shifted data acquisition.

Original languageEnglish
IPCG01R 33/ 48 A I
Patent numberUS2003124732
Filing date03/07/2003
CountryUnited States
Priority date12/04/2001
Priority numberWO2001GB01685
Publication statusPublished - 3 Jul 2003
Externally publishedYes

Bibliographical note

Also published as: US7251519 (B2) WO0179875 (A1) JP2003530927 (A) JP5160008 (B2) EP1272867 (A1) AU4855401 (A)

Cite this

Axelsson, O., Ardenkjær-Larsen, J. H., Månsson, S., Petersson, S., & Leunbach, I. (2003). IPC No. G01R 33/ 48 A I. Mr-method for the in vivo measurement of temperature or ph-value by means of a hyperpolarised contrast agent. (Patent No. US2003124732).