MR-method for the in vivo measurement of temperature or pH-value by means of a hyperpolarised contrast agent

Oskar Axelsson, Jan Henrik Ardenkjær-Larsen, Sven Mansson, Stefan Petersson, Ib Leunbach

Research output: Contribution to journalJournal articleResearch

Abstract

The present invention provides a method of MR investigation of a sample, said method comprising: (i) nuclear spin polarizing a high T1 MR imaging agent which contains in its molecular structure at least two hyperpolarisable nuclei within the same molecule, the frequency difference between the two resonance lines from said nuclei, delta upsilon, being dependent upon either the temperature or the pH of said sample; (ii) administering the nuclear spin polarized MR imaging agent to said sample; (iii) exposing said sample to a radiation at a frequency selected to excite nuclear spin transitions in said MR imaging agent; and (iv) detecting and manipulating magnetic resonance signals from said sample using a single-shot RARE acquisition sequence with shifted data acquisition.
Original languageEnglish
JournalU.S. Patent and Trademark Office. Electronic Official Gazette. Patents
ISSN1554-9550
Publication statusPublished - 2007
Externally publishedYes

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