Morphological Lesions in Mouse Liver and Lungs After Lung Exposure to Carbon Nanotubes

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Morphological Lesions in Mouse Liver and Lungs After Lung Exposure to Carbon Nanotubes. / Szarek, J.; Mortensen, Alicja; Jackson, P.; Saber, A.T.; Kyjovska, Z.O.; Wallin, H.; Vogel, U.; Hougaard, K.S.

In: Journal of Comparative Pathology, Vol. 148, No. 1, 2013, p. 93.

Research output: Contribution to journalConference abstract in journal – Annual report year: 2013Researchpeer-review

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Szarek, J, Mortensen, A, Jackson, P, Saber, AT, Kyjovska, ZO, Wallin, H, Vogel, U & Hougaard, KS 2013, 'Morphological Lesions in Mouse Liver and Lungs After Lung Exposure to Carbon Nanotubes', Journal of Comparative Pathology, vol. 148, no. 1, pp. 93. https://doi.org/10.1016/j.jcpa.2012.11.189

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Szarek, J. ; Mortensen, Alicja ; Jackson, P. ; Saber, A.T. ; Kyjovska, Z.O. ; Wallin, H. ; Vogel, U. ; Hougaard, K.S. / Morphological Lesions in Mouse Liver and Lungs After Lung Exposure to Carbon Nanotubes. In: Journal of Comparative Pathology. 2013 ; Vol. 148, No. 1. pp. 93.

Bibtex

@article{eb31673748924283b9cb6e7130d64b8f,
title = "Morphological Lesions in Mouse Liver and Lungs After Lung Exposure to Carbon Nanotubes",
abstract = "Introduction: Engineered nanoparticles are smaller than 100 nm in at least one direction and designed to improve or achieve new physicochemical properties. Consequently, toxicological properties may also change. Carbon nanotubes have attracted industrial interest due to their unique properties.Materials and Methods: One day before mating, 30 mice (C57BL/6BomTac, Taconic Europe, Denmark) were given 67 μg multi-walled carbon nanotubes (NM-400, Nanocyl, Belgium) intratracheally (group A). A further 30 control mice (group B) received vehicle (Millipore water with 2{\%} mouse serum). Lungs and liver were taken from six animals from each group for histopathological examination (haematoxylin and eosin staining) 6 weeks (A1, B1 group) and 4 months (A2, B2) after exposure.Results: Lungs in A1 mice showed bronchiolar subepithelial oedema and perivascular oedema and sporadic hyperaemia and the presence of macrophages. Oedema was slight in A2 mice, but infiltration of macrophages was more intense. In the liver, microfoci of necrosis, infiltration of inflammatory cells and lesions of Kupffer cells were more intense in A1 than A2 mice.Conclusions: Intratracheal exposure to multi-walled carbon nanotubes caused inflammatory and degenerative lesions in mouse lungs and liver.",
author = "J. Szarek and Alicja Mortensen and P. Jackson and A.T. Saber and Z.O. Kyjovska and H. Wallin and U. Vogel and K.S. Hougaard",
year = "2013",
doi = "10.1016/j.jcpa.2012.11.189",
language = "English",
volume = "148",
pages = "93",
journal = "Journal of Comparative Pathology",
issn = "0021-9975",
publisher = "Elsevier Ltd",
number = "1",

}

RIS

TY - ABST

T1 - Morphological Lesions in Mouse Liver and Lungs After Lung Exposure to Carbon Nanotubes

AU - Szarek, J.

AU - Mortensen, Alicja

AU - Jackson, P.

AU - Saber, A.T.

AU - Kyjovska, Z.O.

AU - Wallin, H.

AU - Vogel, U.

AU - Hougaard, K.S.

PY - 2013

Y1 - 2013

N2 - Introduction: Engineered nanoparticles are smaller than 100 nm in at least one direction and designed to improve or achieve new physicochemical properties. Consequently, toxicological properties may also change. Carbon nanotubes have attracted industrial interest due to their unique properties.Materials and Methods: One day before mating, 30 mice (C57BL/6BomTac, Taconic Europe, Denmark) were given 67 μg multi-walled carbon nanotubes (NM-400, Nanocyl, Belgium) intratracheally (group A). A further 30 control mice (group B) received vehicle (Millipore water with 2% mouse serum). Lungs and liver were taken from six animals from each group for histopathological examination (haematoxylin and eosin staining) 6 weeks (A1, B1 group) and 4 months (A2, B2) after exposure.Results: Lungs in A1 mice showed bronchiolar subepithelial oedema and perivascular oedema and sporadic hyperaemia and the presence of macrophages. Oedema was slight in A2 mice, but infiltration of macrophages was more intense. In the liver, microfoci of necrosis, infiltration of inflammatory cells and lesions of Kupffer cells were more intense in A1 than A2 mice.Conclusions: Intratracheal exposure to multi-walled carbon nanotubes caused inflammatory and degenerative lesions in mouse lungs and liver.

AB - Introduction: Engineered nanoparticles are smaller than 100 nm in at least one direction and designed to improve or achieve new physicochemical properties. Consequently, toxicological properties may also change. Carbon nanotubes have attracted industrial interest due to their unique properties.Materials and Methods: One day before mating, 30 mice (C57BL/6BomTac, Taconic Europe, Denmark) were given 67 μg multi-walled carbon nanotubes (NM-400, Nanocyl, Belgium) intratracheally (group A). A further 30 control mice (group B) received vehicle (Millipore water with 2% mouse serum). Lungs and liver were taken from six animals from each group for histopathological examination (haematoxylin and eosin staining) 6 weeks (A1, B1 group) and 4 months (A2, B2) after exposure.Results: Lungs in A1 mice showed bronchiolar subepithelial oedema and perivascular oedema and sporadic hyperaemia and the presence of macrophages. Oedema was slight in A2 mice, but infiltration of macrophages was more intense. In the liver, microfoci of necrosis, infiltration of inflammatory cells and lesions of Kupffer cells were more intense in A1 than A2 mice.Conclusions: Intratracheal exposure to multi-walled carbon nanotubes caused inflammatory and degenerative lesions in mouse lungs and liver.

U2 - 10.1016/j.jcpa.2012.11.189

DO - 10.1016/j.jcpa.2012.11.189

M3 - Conference abstract in journal

VL - 148

SP - 93

JO - Journal of Comparative Pathology

JF - Journal of Comparative Pathology

SN - 0021-9975

IS - 1

ER -