Monocular Visual Deprivation Suppresses Excitability in Adult Human Visual Cortex

Astrid Rosenstand Lou, Kristoffer Hougaard Madsen, Olaf Bjarne Paulson, Hanne Olsen Julian, Jan Ulrik Prause, Hartwig Roman Siebner, Troels Wesenberg Kjaer

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The adult visual cortex maintains a substantial potential for plasticity in response to a change in visual input. For instance, transcranial magnetic stimulation (TMS) studies have shown that binocular deprivation (BD) increases the cortical excitability for inducing phosphenes with TMS. Here, we employed TMS to trace plastic changes in adult visual cortex before, during, and after 48 h of monocular deprivation (MD) of the right dominant eye. In healthy adult volunteers, MD-induced changes in visual cortex excitability were probed with paired-pulse TMS applied to the left and right occipital cortex. Stimulus–response curves were constructed by recording the intensity of the reported phosphenes evoked in the contralateral visual field at range of TMS intensities. Phosphene measurements revealed that MD produced a rapid and robust decrease in cortical excitability relative to a control condition without MD. The cortical excitability returned to preinterventional baseline levels within 3 h after the end of MD. The results show that in contrast to the excitability increase in response to BD, MD acutely triggers a reversible decrease in visual cortical excitability. This shows that the pattern of visual deprivation has a substantial impact on experience-dependent plasticity of the human visual cortex.
    Original languageEnglish
    JournalCerebral Cortex
    Volume21
    Issue number12
    Pages (from-to)2876-2882
    ISSN1047-3211
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Phosphene threshold
    • Human visual cortex
    • Transcranial magnetic stimulation
    • Monocular deprivation
    • Experience-dependent cortical plasticity

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