Monitoring of living cell attachment and spreading using reverse symmetry waveguide sensing

R. Horvath, H.C. Pedersen, N. Skivesen, D. Selmeczi, N.B. Larsen

    Research output: Contribution to journalJournal articlepeer-review

    Abstract

    The effect of the attachment and spreading of living cells on the modes of a grating coupled reverse symmetry waveguide sensor is investigated in real time. The reverse symmetry design has an increased probing depth into the sample making it well suited for the monitoring of cell morphology. As a result, significant changes in the incoupling peak height and peak shape were observed during cell attachment and spreading. It is suggested that the area under the incoupling peaks reflects the initial cell attachment process, while the mean peak position is mostly governed by the spreading of the cells. (C) 2005 American Institute of Physics.
    Original languageEnglish
    JournalApplied Physics Letters
    Volume86
    Issue number7
    Pages (from-to)071101
    Number of pages3
    ISSN0003-6951
    DOIs
    Publication statusPublished - 2005

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