Monitoring and control of microbioreactors: An expert opinion on development needs

Krist Gernaey, Frank Baganz, Ezequiel Franco-Lara, Frank Kensy, Ulrich Krühne, Marc Luebberstedt, Uwe Marx, Eva Palmqvist, Andreas Schmid, Frank Schubert, Carl-Fredrik Mandenius

Research output: Contribution to journalJournal articleResearchpeer-review


This perspective article is based on an expert panel review on microbioreactor applications in biochemical
and biomedical engineering that was organized by the M3C (measurement, monitoring, modelling and control) Working Group of the European Section of Biochemical Engineering Science (ESBES) in the European Federation of Biotechnology (EFB). The aim of the panel was to provide an updated view on the present status of the subject and to identify critical needs and issues for furthering the successful development of microbioreactor monitoring and control. This will benefit future bioprocess development and in vitro toxicity testing. The article concludes with a set
of recommendations for extended use and further development of microbioreactors.
Original languageEnglish
JournalBiotechnology Journal
Issue number10
Pages (from-to)1308-1314
Publication statusPublished - 2012


  • Bioreactor control
  • High-throughput screening
  • In vitro testing
  • Microfluidics
  • On-line monitoring


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