Molecular Thermodynamic Modeling and Design of Microencapsulation Systems for Drug Delivery

Jens Abildskov, John P. O’Connell

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A systematic design strategy is given for computer-aided design of microparticle drug-delivery systems produced by solvent evaporation. In particular, design of solvents, polymer material, and external phase composition are considered for the case when the active ingredient is known. The procedure is based on fundamental thermodynamic relations and group contributions to properties of pure species (solvent, active ingredient and polymer) and their mixtures. The method is intended for pharmaceuticals with complex molecular structures, for which limited experimental information is known. Case studies of solvent design are given.
Original languageEnglish
JournalJournal of Chemical and Engineering Data
Volume56
Issue number4
Pages (from-to)1229-1237
ISSN0021-9568
DOIs
Publication statusPublished - 2011

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