Molecular Recognition in NADPH-Dependent Plant Thioredoxin Systems-Catalytic Mechanisms, Structural Snapshots and Target Identifications

Per Hägglund, Kristine Groth Kirkensgaard, Kenji Maeda, Christine Finnie, Anette Henriksen, Birte Svensson

    Research output: Contribution to journalReviewResearchpeer-review

    Abstract

    NADPH-dependent thioredoxin Systems (NTS) control enzymatic activities and provide reducing equivalents to metabolic pathways in all types of organisms. from bacteria to mammals In these redox systems, thioredoxin reduces disulfide bonds in target proteins and receives electrons from NADPH via thioredoxin reductase (NTR). Plant NTS were first discovered in wheat seeds some 30 years ago and were demonstrated to play a key role in the seed germination process Since then, NTS have been identified in a large. variety of photosynthetic organisms. and,in organelle-specific pattern for their cellular localization is established The last decade has witnessed a remarkable expansion of the knowledge about these systems and novel molecular architectures. catalytic mechanisms and target proteins have been revealed. In general, these findings have provided a wealth of information about the physiological role and molecular mechanisms of plant NTS, and this chapter will highlight some of the recent developments in this area
    Original languageEnglish
    JournalAdvances in Botanical Research
    Volume52
    Pages (from-to)461–495
    ISSN0065-2296
    DOIs
    Publication statusPublished - 2009

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