Molecular mechanisms and topological consequences of drastic chromosomal rearrangements of muntjac deer

Yuan Yin, Huizhong Fan, Botong Zhou, Yibo Hu, Guangyi Fan, Jinhuan Wang, Fan Zhou, Wenhui Nie, Chenzhou Zhang, Lin Liu, Zhenyu Zhong, Wenbo Zhu, Guichun Liu, Zeshan Lin, Chang Liu, Jiong Zhou, Guangping Huang, Zihe Li, Jianping Yu, Yaolei ZhangYue Yang, Bingzhao Zhuo, Baowei Zhang, Jiang Chang, Haiyuan Qian, Yingmei Peng, Xianqing Chen, Lei Chen, Zhipeng Li, Qi Zhou*, Wen Wang*, Fuwen Wei*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Muntjac deer have experienced drastic karyotype changes during their speciation, making it an ideal model for studying mechanisms and functional consequences of mammalian chromosome evolution. Here we generated chromosome-level genomes for Hydropotes inermis (2n = 70), Muntiacus reevesi (2n = 46), female and male M. crinifrons (2n = 8/9) and a contig-level genome for M. gongshanensis (2n = 8/9). These high-quality genomes combined with Hi-C data allowed us to reveal the evolution of 3D chromatin architectures during mammalian chromosome evolution. We find that the chromosome fusion events of muntjac species did not alter the A/B compartment structure and topologically associated domains near the fusion sites, but new chromatin interactions were gradually established across the fusion sites. The recently borne neo-Y chromosome of M. crinifrons, which underwent male-specific inversions, has dramatically restructured chromatin compartments, recapitulating the early evolution of canonical mammalian Y chromosomes. We also reveal that a complex structure containing unique centromeric satellite, truncated telomeric and palindrome repeats might have mediated muntjacs’ recurrent chromosome fusions. These results provide insights into the recurrent chromosome tandem fusion in muntjacs, early evolution of mammalian sex chromosomes, and reveal how chromosome rearrangements can reshape the 3D chromatin regulatory conformations during species evolution.
Original languageEnglish
Article number6858
JournalNature Communications
Volume12
Issue number1
Number of pages15
ISSN2041-1723
DOIs
Publication statusPublished - 2021

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