Molecular imaging using hyperpolarized 13C

K Golman, L E Olsson, O Axelsson, Sven-Erik Månsson, Magnus Karlsson, J S Petersson

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this modality has limited the clinical use to imaging of water protons. With hyperpolarization techniques, the signal from a given number of nuclear spins can be raised more than 100 000 times. The strong signal enhancement enables imaging of nuclei other than protons, e.g. (13)C and (15)N, and their molecular distribution in vivo can be visualized in a clinically relevant time window. This article reviews different hyperpolarization techniques and some of the many application areas. As an example, experiments are presented where hyperpolarized (13)C nuclei have been injected into rabbits, followed by rapid (13)C MRI with high spatial resolution (scan time
Original languageEnglish
JournalBritish Journal of Radiology
Volume76 Spec No 2
Pages (from-to)S118-27
ISSN0007-1285
DOIs
Publication statusPublished - 2003
Externally publishedYes

Keywords

  • Animals
  • Carbon Isotopes
  • Humans
  • Lung Diseases
  • Magnetic Resonance Imaging
  • Male
  • Models, Chemical
  • Rabbits
  • Thermodynamics

Cite this

Golman, K., Olsson, L. E., Axelsson, O., Månsson, S-E., Karlsson, M., & Petersson, J. S. (2003). Molecular imaging using hyperpolarized 13C. British Journal of Radiology, 76 Spec No 2, S118-27. https://doi.org/10.1259/bjr/26631666