Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage

Cecilie Freja Kjelgaard-Petersen, Neha Sharma, Ashref Kayed, Britt Christensen, Morten Karsdal, Anne-C Bay-Jensen, Christian S. Thudium

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Abstract

Background/Purpose:
Several inflammatory cytokines and intracellular signaling pathways have been targeted in drug development with varying clinical results. Improved understanding of the intracellular signaling’s modulation of the extracellular matrix turnover could aid in selecting novel anti-inflammatory treatments for inflammatory arthritis. The aim of this study was to investigate the effect of small molecule inhibitors targeting 4 main pro-inflammatory signaling pathways (p38, Syk, IκBα, and STAT) on Oncostatin M (OSM) and Tumor Necrosis Factor α (TNFα) stimulated cartilage.
Original languageEnglish
Article number969
JournalArthritis and Rheumatology
Volume69
Issue numberSuppl. 10
ISSN2326-5205
Publication statusPublished - 2017
Event2017 ACR/ARHP Annual Meeting - San Diego, United States
Duration: 3 Nov 20178 Nov 2017
http://acrabstracts.org/meetings/2017-acrarhp-annual-meeting/

Conference

Conference2017 ACR/ARHP Annual Meeting
CountryUnited States
CitySan Diego
Period03/11/201708/11/2017
Internet address

Cite this

Kjelgaard-Petersen, C. F., Sharma, N., Kayed, A., Christensen, B., Karsdal, M., Bay-Jensen, A-C., & Thudium, C. S. (2017). Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage. Arthritis and Rheumatology, 69(Suppl. 10), [969].