Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage

Cecilie Freja Kjelgaard-Petersen; Neha Sharma; Ashref Kayed; Britt Christensen; Morten Karsdal; Anne-C Bay-Jensen; Christian S. Thudium

Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage

Cecilie Freja Kjelgaard-Petersen, Neha Sharma, Ashref Kayed, Britt Christensen, Morten Karsdal, Anne-C Bay-Jensen, Christian S. Thudium

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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Abstract

Background/Purpose:
Several inflammatory cytokines and intracellular signaling pathways have been targeted in drug development with varying clinical results. Improved understanding of the intracellular signaling’s modulation of the extracellular matrix turnover could aid in selecting novel anti-inflammatory treatments for inflammatory arthritis. The aim of this study was to investigate the effect of small molecule inhibitors targeting 4 main pro-inflammatory signaling pathways (p38, Syk, IκBα, and STAT) on Oncostatin M (OSM) and Tumor Necrosis Factor α (TNFα) stimulated cartilage.

Original language	English
Article number	969
Journal	Arthritis and Rheumatology
Volume	69
Issue number	Suppl. 10
ISSN	2326-5205
Publication status	Published - 2017
Event	2017 ACR/ARHP Annual Meeting - San Diego, United States Duration: 3 Nov 2017 → 8 Nov 2017 http://acrabstracts.org/meetings/2017-acrarhp-annual-meeting/

Conference

Conference	2017 ACR/ARHP Annual Meeting
Country/Territory	United States
City	San Diego
Period	03/11/2017 → 08/11/2017
Internet address	http://acrabstracts.org/meetings/2017-acrarhp-annual-meeting/

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title = "Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage",

abstract = "Background/Purpose:Several inflammatory cytokines and intracellular signaling pathways have been targeted in drug development with varying clinical results. Improved understanding of the intracellular signaling{\textquoteright}s modulation of the extracellular matrix turnover could aid in selecting novel anti-inflammatory treatments for inflammatory arthritis. The aim of this study was to investigate the effect of small molecule inhibitors targeting 4 main pro-inflammatory signaling pathways (p38, Syk, IκBα, and STAT) on Oncostatin M (OSM) and Tumor Necrosis Factor α (TNFα) stimulated cartilage.",

author = "Kjelgaard-Petersen, {Cecilie Freja} and Neha Sharma and Ashref Kayed and Britt Christensen and Morten Karsdal and Anne-C Bay-Jensen and Thudium, {Christian S.}",

year = "2017",

language = "English",

volume = "69",

journal = "Arthritis and Rheumatology",

issn = "2326-5205",

publisher = "Wiley",

number = "Suppl. 10",

note = "2017 ACR/ARHP Annual Meeting ; Conference date: 03-11-2017 Through 08-11-2017",

url = "http://acrabstracts.org/meetings/2017-acrarhp-annual-meeting/",

}

Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage. / Kjelgaard-Petersen, Cecilie Freja; Sharma, Neha; Kayed, Ashref et al.
In: Arthritis and Rheumatology, Vol. 69, No. Suppl. 10, 969, 2017.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

TY - ABST

T1 - Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage

AU - Kjelgaard-Petersen, Cecilie Freja

AU - Sharma, Neha

AU - Kayed, Ashref

AU - Christensen, Britt

AU - Karsdal, Morten

AU - Bay-Jensen, Anne-C

AU - Thudium, Christian S.

PY - 2017

Y1 - 2017

N2 - Background/Purpose:Several inflammatory cytokines and intracellular signaling pathways have been targeted in drug development with varying clinical results. Improved understanding of the intracellular signaling’s modulation of the extracellular matrix turnover could aid in selecting novel anti-inflammatory treatments for inflammatory arthritis. The aim of this study was to investigate the effect of small molecule inhibitors targeting 4 main pro-inflammatory signaling pathways (p38, Syk, IκBα, and STAT) on Oncostatin M (OSM) and Tumor Necrosis Factor α (TNFα) stimulated cartilage.

AB - Background/Purpose:Several inflammatory cytokines and intracellular signaling pathways have been targeted in drug development with varying clinical results. Improved understanding of the intracellular signaling’s modulation of the extracellular matrix turnover could aid in selecting novel anti-inflammatory treatments for inflammatory arthritis. The aim of this study was to investigate the effect of small molecule inhibitors targeting 4 main pro-inflammatory signaling pathways (p38, Syk, IκBα, and STAT) on Oncostatin M (OSM) and Tumor Necrosis Factor α (TNFα) stimulated cartilage.

M3 - Conference abstract in journal

SN - 2326-5205

VL - 69

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

IS - Suppl. 10

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T2 - 2017 ACR/ARHP Annual Meeting

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Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage

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