Modular, Lightweight, Wireless Potentiostat-on-a-Disc for Electrochemical Detection in Centrifugal Microfluidics

Sriram Thoppe Rajendran, Ermes Scarano, Max H. Bergkamp, Alessandro M. Capria, Chung-Hsiang Cheng, Kuldeep Sanger, Giorgio Ferrari, Line Hagner Nielsen, En Te Hwu, Kinga Zor, Anja Boisen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Interfacing electrochemical sensors in a lab-on-a-disc (LoD) system with a potentiostat is often tedious and challenging. We here present the first multichannel, modular, lightweight, and wirelessly powered, custom-built potentiostat-on-a-disc (PoD) for centrifugal microfluidic applications. The developed potentiostat is in the form factor of a typical digital video disc (DVD) and weighs only 127 g. The design of the potentiostat facilitates easy and robust interfacing with the electrodes in the LoD system, while enabling real-time electrochemical detection during rotation. The device can perform different electroanalytical techniques such as cyclic voltammetry, square wave voltammetry, and amperometry while being controlled by custom-made software. Measurements were conducted with and without rotation using both in-house fabricated and commercial electrodes. The performance of the PoD was in good agreement with the results obtained using a commercial potentiostat with a measured current resolution of 200 pA. As a proof of concept, we performed a real-time release study of an electrochemically active compound from microdevices used for drug delivery.
Original languageEnglish
JournalAnalytical chemistry
Volume91
Pages (from-to)11620-11628
ISSN0003-2700
DOIs
Publication statusPublished - 2019

Cite this

Thoppe Rajendran, Sriram ; Scarano, Ermes ; Bergkamp, Max H. ; Capria, Alessandro M. ; Cheng, Chung-Hsiang ; Sanger, Kuldeep ; Ferrari, Giorgio ; Nielsen, Line Hagner ; Hwu, En Te ; Zor, Kinga ; Boisen, Anja. / Modular, Lightweight, Wireless Potentiostat-on-a-Disc for Electrochemical Detection in Centrifugal Microfluidics. In: Analytical chemistry. 2019 ; Vol. 91. pp. 11620-11628.
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title = "Modular, Lightweight, Wireless Potentiostat-on-a-Disc for Electrochemical Detection in Centrifugal Microfluidics",
abstract = "Interfacing electrochemical sensors in a lab-on-a-disc (LoD) system with a potentiostat is often tedious and challenging. We here present the first multichannel, modular, lightweight, and wirelessly powered, custom-built potentiostat-on-a-disc (PoD) for centrifugal microfluidic applications. The developed potentiostat is in the form factor of a typical digital video disc (DVD) and weighs only 127 g. The design of the potentiostat facilitates easy and robust interfacing with the electrodes in the LoD system, while enabling real-time electrochemical detection during rotation. The device can perform different electroanalytical techniques such as cyclic voltammetry, square wave voltammetry, and amperometry while being controlled by custom-made software. Measurements were conducted with and without rotation using both in-house fabricated and commercial electrodes. The performance of the PoD was in good agreement with the results obtained using a commercial potentiostat with a measured current resolution of 200 pA. As a proof of concept, we performed a real-time release study of an electrochemically active compound from microdevices used for drug delivery.",
author = "{Thoppe Rajendran}, Sriram and Ermes Scarano and Bergkamp, {Max H.} and Capria, {Alessandro M.} and Chung-Hsiang Cheng and Kuldeep Sanger and Giorgio Ferrari and Nielsen, {Line Hagner} and Hwu, {En Te} and Kinga Zor and Anja Boisen",
year = "2019",
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language = "English",
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Modular, Lightweight, Wireless Potentiostat-on-a-Disc for Electrochemical Detection in Centrifugal Microfluidics. / Thoppe Rajendran, Sriram; Scarano, Ermes; Bergkamp, Max H.; Capria, Alessandro M.; Cheng, Chung-Hsiang; Sanger, Kuldeep; Ferrari, Giorgio; Nielsen, Line Hagner; Hwu, En Te; Zor, Kinga; Boisen, Anja.

In: Analytical chemistry, Vol. 91, 2019, p. 11620-11628.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Modular, Lightweight, Wireless Potentiostat-on-a-Disc for Electrochemical Detection in Centrifugal Microfluidics

AU - Thoppe Rajendran, Sriram

AU - Scarano, Ermes

AU - Bergkamp, Max H.

AU - Capria, Alessandro M.

AU - Cheng, Chung-Hsiang

AU - Sanger, Kuldeep

AU - Ferrari, Giorgio

AU - Nielsen, Line Hagner

AU - Hwu, En Te

AU - Zor, Kinga

AU - Boisen, Anja

PY - 2019

Y1 - 2019

N2 - Interfacing electrochemical sensors in a lab-on-a-disc (LoD) system with a potentiostat is often tedious and challenging. We here present the first multichannel, modular, lightweight, and wirelessly powered, custom-built potentiostat-on-a-disc (PoD) for centrifugal microfluidic applications. The developed potentiostat is in the form factor of a typical digital video disc (DVD) and weighs only 127 g. The design of the potentiostat facilitates easy and robust interfacing with the electrodes in the LoD system, while enabling real-time electrochemical detection during rotation. The device can perform different electroanalytical techniques such as cyclic voltammetry, square wave voltammetry, and amperometry while being controlled by custom-made software. Measurements were conducted with and without rotation using both in-house fabricated and commercial electrodes. The performance of the PoD was in good agreement with the results obtained using a commercial potentiostat with a measured current resolution of 200 pA. As a proof of concept, we performed a real-time release study of an electrochemically active compound from microdevices used for drug delivery.

AB - Interfacing electrochemical sensors in a lab-on-a-disc (LoD) system with a potentiostat is often tedious and challenging. We here present the first multichannel, modular, lightweight, and wirelessly powered, custom-built potentiostat-on-a-disc (PoD) for centrifugal microfluidic applications. The developed potentiostat is in the form factor of a typical digital video disc (DVD) and weighs only 127 g. The design of the potentiostat facilitates easy and robust interfacing with the electrodes in the LoD system, while enabling real-time electrochemical detection during rotation. The device can perform different electroanalytical techniques such as cyclic voltammetry, square wave voltammetry, and amperometry while being controlled by custom-made software. Measurements were conducted with and without rotation using both in-house fabricated and commercial electrodes. The performance of the PoD was in good agreement with the results obtained using a commercial potentiostat with a measured current resolution of 200 pA. As a proof of concept, we performed a real-time release study of an electrochemically active compound from microdevices used for drug delivery.

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JO - Analytical Chemistry

JF - Analytical Chemistry

SN - 0003-2700

ER -