Modular approach to novel chiral aryl-ferrocenyl phosphines by Suzuki cross-coupling

Jakob Feldthusen Jensen, Inger Søtofte, H.O. Sorensen, Mogens Johannsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Two novel planar chiral and atropisomeric P,N and P,O aryl-ferrocenyl ligand systems have been developed. The strategy is short and involves a new synthetic approach to aryl-ferrocenyl compounds via a Suzuki cross-coupling procedure. The modular design can easily give access to variety of chiral mono- and bidentate ligands. Two simple derivatives of a novel chiral bidenate P,N ligand belonging to the MOPF family have been synthesized and tested in the enantioselective copper-catalyzed addition of diethyl zinc to an enone and a "difficult" diester. Moderate to excellent yields and enantioselectivities up to 58% were obtained using 1 mol % Cu(OTf)(2) and 1.5 mol % chiral ligand.
Original languageEnglish
JournalJournal of organic chemistry
Volume68
Issue number4
Pages (from-to)1258-1265
ISSN0022-3263
Publication statusPublished - 2002

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