Modifying Yeast Tolerance to Inhibitory Conditions of Ethanol Production Processes

Luis Caspeta, Tania Castillo, Jens Nielsen

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Saccharomyces cerevisiae strains having a broad range of substrate utilization, rapid substrate consumption, and conversion to ethanol, as well as good tolerance to inhibitory conditions are ideal for cost-competitive ethanol production from lignocellulose. A major drawback to directly design S. cerevisiae tolerance to inhibitory conditions of lignocellulosic ethanol production processes is the lack of knowledge about basic aspects of its cellular signaling network in response to stress. Here, we highlight the inhibitory conditions found in ethanol production processes, the targeted cellular functions, the key contributions of integrated -omics analysis to reveal cellular stress responses according to these inhibitors, and current status on design-based engineering of tolerant and efficient S. cerevisiae strains for ethanol production from lignocellulose.
Original languageEnglish
Article number184
JournalFrontiers in Bioengineering and Biotechnology
Number of pages15
Publication statusPublished - 2015

Bibliographical note

© 2015 Caspeta, Castillo and Nielsen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.


  • Cellular stress response
  • Design-based engineering
  • Ethanol production process
  • Inhibitory environment
  • Integrated -omics analysis
  • Stress tolerance
  • Yeast


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