Modification of FMDV anti-host defense mechanism

Suhua Guan, Graham Belsham

    Research output: Contribution to conferencePosterResearchpeer-review

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    Foot-and-mouth disease virus (FMDV) is the etiologic agent of FMD, an infectious and sometimes fatal viral disease that affects cloven-hoofed animals. The FMDV genome encodes a large polyprotein, the first component of which is the Leader protein. Unusually, within the picornavirus family, the FMDV Leader protein (Lpro) is a protease. This protease induces a very rapid inhibition of host cell cap-dependent protein synthesis within infected cells. This results from cleavage of the cellular translation initiation factor eIF4G. Translation of the viral RNA is unaffected since it is dependent on an internal ribosome entry site (IRES) that directs cap-independent translation initiation. Lpro also releases itself from the virus capsid precursor (at the L/P1 junction). The aim of this project is to identify amino acids that are essential for eIF4G cleavage but not for the self-processing. This study may allow design of mutant viruses that are deficient in blocking host cell responses to infection (e.g. interferon induction) and assist in the rational design of antiviral agents targeting this process.
    Original languageEnglish
    Publication date2014
    Number of pages1
    Publication statusPublished - 2014
    Event8th Annual Meeting of Epizone: Primed for tomorrow - DGI Byen, Copenhagen, Denmark
    Duration: 23 Sep 201425 Sep 2014
    Conference number: 8


    Conference8th Annual Meeting of Epizone
    LocationDGI Byen
    Internet address


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