Modelling for Bio-,Agro- and Pharma-Applications

Ricardo Morales Rodriguez, Ravendra Singh, Ian Cameron, Rafiqul Gani

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review


This chapter considers a range of modelling applications drawn from biological, agrochemical and pharma fields. Microcapsule controlled release of an active ingredient is considered through a time dependent model. Burst-time and lag-time effects are considered and the model adopts a multiscale approach for meso and microscale partial models. The specific case study of codeine release is examined. As a bio- application, a batch fermentation process is modelled. This involves the generation of a pre-cursor compound for insulin production.The plant involves a number of coupled unit operations such as mixers, fermenter as well as air compression and filtration. Milk pasteurisation is another application considered in this chapter. The intention is to look at the temperature profile of milk through the process, which has 4 distinct phases. Other case studies in this chapter include a dynamic model of a milling process within pharmaceutical production as well as a dynamic model representing a fluidised granulation bed for pharma products. The final model considers the tablet pressing process.
Original languageEnglish
Title of host publicationProduct and Process Modelling : A Case Study Approach
EditorsIan Cameron, Rafiqul Gani
Number of pages557
Publication date2011
ISBN (Print)978-0-444-53161-2
Publication statusPublished - 2011


  • Bio-applications
  • Filtration
  • Microcapsules
  • Agrochemical
  • Milk pasteurisation
  • Tablet pressing
  • Codeine release
  • Batch fermentation
  • Fluidised granulation


Dive into the research topics of 'Modelling for Bio-,Agro- and Pharma-Applications'. Together they form a unique fingerprint.

Cite this