Modelling and simulation of a U-loop Reactor for Single Cell Protein Production

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In this work, two approaches of modelling a one phase U-loop reactor are presented. A simple CSTR model consisting of first-principles dynamic process equations was implemented in Matlab. The results give a good indication of the basic understanding of the effect of changing operation conditions on process performance. For a given product yield, the work investigates how process parameters such as dilution rate (D) or the methanol concentration should be selected to optimize the production. Nevertheless, this simple model exhibits some limitations hindering the development of the optimal operation procedure, such as the impact of the reactor geometry on the operating conditions. Some main hydrodynamic characterization parameters, like the mixing and the mass transfer coefficient kLa are geometry dependent.
The second modelling approach attempts to overcome the above-mentioned problems. A three-dimensional one-phase model using Computational Fluid Dynamics (CFD) methods is proposed. By introducing the momentum balances in the simulation, the results can capture the flow velocity fields in three dimensions. It is thereby possible to indicate the influence of the geometric design on the production yield. This methodology allows further research on the effect of design choices on optimal operation, such as the determination of where to locate the substrate input, the static mixer position or the gas injection position.
Original languageEnglish
Title of host publication Proceedings of the 26th European Symposium on Computer Aided Process Engineering
EditorsZdravko Kravanja, Miloš Bogataj
Publication date2016
ISBN (Electronic)978-0-444-63428-3
Publication statusPublished - 2016
Event26th European Symposium on Computer-Aided Process Engineering - Grand Hotel Bernardin Congress Centre, Portorož , Slovenia
Duration: 12 Jun 201615 Jun 2016


Conference26th European Symposium on Computer-Aided Process Engineering
LocationGrand Hotel Bernardin Congress Centre
Internet address


  • Net Present Value
  • Uncertainty analysis
  • Risk
  • Isobutanol


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