Modelling and simulation of a transketolase mediated reaction: Sensitivity analysis of kinetic parameters

N.A. Sayar, B.H. Chen, G.J. Lye, John Woodley

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In this paper we have used a proposed mathematical model, describing the carbon-carbon bond format ion reaction between beta-hydroxypyruvate and glycolaldehyde to synthesise L-erythrulose, catalysed by the enzyme transketolase, for the analysis of the sensitivity of the process to its kinetic parameters. The model was validated with experimental data. As a conclusion, kinetic parameters with a possible positive impact on reaction performance were identified and assessed in relation to operating conditions. This resulted in the identification of suitable catalyst and process development targets. (C) 2009 Elsevier B.V. All rights reserved.
Original languageEnglish
JournalBiochemical Engineering Journal
Volume47
Issue number1-3
Pages (from-to)1-9
ISSN1369-703X
DOIs
Publication statusPublished - 2009

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