Modeling the cost of eradicating livestock-associated methicillin-resistant staphylococcus aureus in countries with a high proportion of positive herds

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Modeling the cost of eradicating livestock-associated methicillin-resistant staphylococcus aureus in countries with a high proportion of positive herds. / Olsen, J.V.; Calvo Artavia, F. F.; Sandøe, P.; Toft, N.

In: Preventive Veterinary Medicine, Vol. 158, 2018, p. 97-105.

Research output: Contribution to journalJournal article – Annual report year: 2018Researchpeer-review

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@article{bfbb928714e64e21911cee81f6586fd0,
title = "Modeling the cost of eradicating livestock-associated methicillin-resistant staphylococcus aureus in countries with a high proportion of positive herds",
abstract = "Due to an increased incidence of human infections, livestock-associated methicillin-resistant Staphylococcus Aureus (LA-MRSA) in pigs and its spread into the human population has been a major public and political issue in Denmark. Similar concerns are also being raised about LA-MRSA in other Western European countries. At a time when the proportion of LA-MRSA-positive pig farms was low, Norway adopted a ‘trace and destroy’ strategy aimed at keeping LA-MRSA out of the pig population. However, to date, no country with a high proportion of LAMRSA-positive pig herds has chosen to use an eradication strategy. This study analyses the cost and complexities of conducting an LA-MRSA eradication program in a situation where a large proportion of herds are positive. The total cost of the eradication program was estimated based on the following components: 1) planning, 2) monitoring and testing, 3) cleaning and disinfection, 4) production gains and losses, 5) net reduction in breeding exports, and 6) loss of genetic progress, including the costs of a mitigating caesarean section strategy in breeding herds. Costs were related to the depopulation of 1 million sows, to gilt supply (as this was an important limiting factor during an eradication program in Denmark), and to aggregated losses linked to a temporary halt on breeding progress. Using conservative assumptions, the total eradication costs were estimated at €1.8 billion, broken down into: planning costs (3{\%}), monitoring and testing (6{\%}), cleaning and disinfection (19{\%}), production gains and losses (33{\%}), net loss from breeding exports (19{\%}) and loss of genetic progress (20{\%}). Thelong-term effects of an LA-MRSA eradication program for Danish pig production were uncertain and were therefore not taken into account in the analysis.",
keywords = "LA-MRSA, CC398, Eradiction, Cost analysis",
author = "J.V. Olsen and {Calvo Artavia}, {F. F.} and P. Sand{\o}e and N. Toft",
year = "2018",
doi = "10.1016/j.prevetmed.2018.07.010",
language = "English",
volume = "158",
pages = "97--105",
journal = "Preventive Veterinary Medicine",
issn = "0167-5877",
publisher = "Elsevier B.V.",

}

RIS

TY - JOUR

T1 - Modeling the cost of eradicating livestock-associated methicillin-resistant staphylococcus aureus in countries with a high proportion of positive herds

AU - Olsen, J.V.

AU - Calvo Artavia, F. F.

AU - Sandøe, P.

AU - Toft, N.

PY - 2018

Y1 - 2018

N2 - Due to an increased incidence of human infections, livestock-associated methicillin-resistant Staphylococcus Aureus (LA-MRSA) in pigs and its spread into the human population has been a major public and political issue in Denmark. Similar concerns are also being raised about LA-MRSA in other Western European countries. At a time when the proportion of LA-MRSA-positive pig farms was low, Norway adopted a ‘trace and destroy’ strategy aimed at keeping LA-MRSA out of the pig population. However, to date, no country with a high proportion of LAMRSA-positive pig herds has chosen to use an eradication strategy. This study analyses the cost and complexities of conducting an LA-MRSA eradication program in a situation where a large proportion of herds are positive. The total cost of the eradication program was estimated based on the following components: 1) planning, 2) monitoring and testing, 3) cleaning and disinfection, 4) production gains and losses, 5) net reduction in breeding exports, and 6) loss of genetic progress, including the costs of a mitigating caesarean section strategy in breeding herds. Costs were related to the depopulation of 1 million sows, to gilt supply (as this was an important limiting factor during an eradication program in Denmark), and to aggregated losses linked to a temporary halt on breeding progress. Using conservative assumptions, the total eradication costs were estimated at €1.8 billion, broken down into: planning costs (3%), monitoring and testing (6%), cleaning and disinfection (19%), production gains and losses (33%), net loss from breeding exports (19%) and loss of genetic progress (20%). Thelong-term effects of an LA-MRSA eradication program for Danish pig production were uncertain and were therefore not taken into account in the analysis.

AB - Due to an increased incidence of human infections, livestock-associated methicillin-resistant Staphylococcus Aureus (LA-MRSA) in pigs and its spread into the human population has been a major public and political issue in Denmark. Similar concerns are also being raised about LA-MRSA in other Western European countries. At a time when the proportion of LA-MRSA-positive pig farms was low, Norway adopted a ‘trace and destroy’ strategy aimed at keeping LA-MRSA out of the pig population. However, to date, no country with a high proportion of LAMRSA-positive pig herds has chosen to use an eradication strategy. This study analyses the cost and complexities of conducting an LA-MRSA eradication program in a situation where a large proportion of herds are positive. The total cost of the eradication program was estimated based on the following components: 1) planning, 2) monitoring and testing, 3) cleaning and disinfection, 4) production gains and losses, 5) net reduction in breeding exports, and 6) loss of genetic progress, including the costs of a mitigating caesarean section strategy in breeding herds. Costs were related to the depopulation of 1 million sows, to gilt supply (as this was an important limiting factor during an eradication program in Denmark), and to aggregated losses linked to a temporary halt on breeding progress. Using conservative assumptions, the total eradication costs were estimated at €1.8 billion, broken down into: planning costs (3%), monitoring and testing (6%), cleaning and disinfection (19%), production gains and losses (33%), net loss from breeding exports (19%) and loss of genetic progress (20%). Thelong-term effects of an LA-MRSA eradication program for Danish pig production were uncertain and were therefore not taken into account in the analysis.

KW - LA-MRSA

KW - CC398

KW - Eradiction

KW - Cost analysis

U2 - 10.1016/j.prevetmed.2018.07.010

DO - 10.1016/j.prevetmed.2018.07.010

M3 - Journal article

VL - 158

SP - 97

EP - 105

JO - Preventive Veterinary Medicine

JF - Preventive Veterinary Medicine

SN - 0167-5877

ER -