TY - JOUR
T1 - Modeling of glutamate-induced dynamical patterns
AU - Faurby-Bentzen, Christian Krefeld
AU - Zhabotinsky, A.M.
AU - Laugesen, Jakob Lund
PY - 2009
Y1 - 2009
N2 - Based on established physiological mechanisms, the paper presents a detailed computer model, which supports the hypothesis that temporal lobe epilepsy may be caused by failure of glutamate reuptake from the extracellular space. The elevated glutamate concentration causes an increased activation of NMDA receptors in pyramidal neurons, which in turn leads to neuronal dynamics that is qualitatively identical to epileptiform activity. We identify by chaos analysis a surprising possibility that muscarinergic receptors can help the system out of a chaotic regime.
AB - Based on established physiological mechanisms, the paper presents a detailed computer model, which supports the hypothesis that temporal lobe epilepsy may be caused by failure of glutamate reuptake from the extracellular space. The elevated glutamate concentration causes an increased activation of NMDA receptors in pyramidal neurons, which in turn leads to neuronal dynamics that is qualitatively identical to epileptiform activity. We identify by chaos analysis a surprising possibility that muscarinergic receptors can help the system out of a chaotic regime.
U2 - 10.1142/S0129065709002105
DO - 10.1142/S0129065709002105
M3 - Journal article
SN - 0129-0657
VL - 19
SP - 395
EP - 407
JO - International Journal of Neural Systems
JF - International Journal of Neural Systems
IS - 6
ER -