Modeling of glutamate-induced dynamical patterns

Christian Krefeld Faurby-Bentzen, A.M. Zhabotinsky, Jakob Lund Laugesen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Based on established physiological mechanisms, the paper presents a detailed computer model, which supports the hypothesis that temporal lobe epilepsy may be caused by failure of glutamate reuptake from the extracellular space. The elevated glutamate concentration causes an increased activation of NMDA receptors in pyramidal neurons, which in turn leads to neuronal dynamics that is qualitatively identical to epileptiform activity. We identify by chaos analysis a surprising possibility that muscarinergic receptors can help the system out of a chaotic regime.
Original languageEnglish
JournalInternational Journal of Neural Systems
Volume19
Issue number6
Pages (from-to)395-407
ISSN0129-0657
Publication statusPublished - 2009

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