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Abstract
Acoustoﬂuidics is the interdisciplinary combined ﬁeld of ultrasound acoustics and microﬂuidics. The interplay between acoustic standing pressure and velocity waves and the laminar channel ﬂows in microchips enable reproducible and controllable manipulation of the position of suspended cells and particles as small as on the nanometerscale. Acoustoﬂuidics is an emerging ﬁeld and the bulk of the theoretical foundation experimentalists rely on when designing new devices is based on idealized systems and approximated twodimensional numerical models. These create a good understanding of systems and can explain most experimentally observed phenomena. As the acoustoﬂuidic community grows the channel designs grow in amount and complexity. Hence, a move away from idealized and approximated systems towards more complete, threedimensional numerical models may be necessary. That is the topic of this thesis. In this thesis we document the gradual development of a numerical model intended to accurately model complex acoustoﬂuidic microdevices. The model grows from a simpel twodimensional model containing few elements to a threedimensional model capable of modeling microdevices to scale. Along the development we verify the model predictions using analytical and experimental results. Additionally, we use it to draw out knowledge about the rapidly oscillating acoustic ﬁelds that are not readily measured experimentally, thus gaining insight in the physical phenomena happening in the devices. Finally, we use the predictive powers of the model as a design tool to improve on existing microdevices and even creating an entirely new one.
Original language  English 

Place of Publication  Lyngby, Denmark 

Publisher  Technical University of Denmark 
Number of pages  151 
Publication status  Published  2019 
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 1 Finished

Systemlevel simulation and automation of microscale acoustofluidics for biotechnology
Skov, N. R., Bruus, H., Wiklund, M., Thomsen, E. V., Dual, J., Guo, X. & Stokke, B. T.
Technical University of Denmark
15/06/2016 → 30/09/2019
Project: PhD