Modeling of biopharmaceutical processes. Part 2: Process chromatography unit operation

Process modeling can be a useful tool to aid in process development, process optimization, and process scale-up. When modeling a chromatography process, one must first select the appropriate models that describe the mass transfer and adsorption that occurs within the porous adsorbent. The theoretical understanding of chromatographic behavior can augment available experimental data and aid in the design of specific experiments to develop a more complete understanding of the behavior of a unit operation.