Modeling of a photoplethysmographic (PPG) waveform through monte carlo as a method of deriving blood pressure in individuals with obesity.

Tananant Boonya-Ananta*, Andres J. Rodriguez, Anders K. Hansen, Joshua D. Hutcheson, Jessica C. Ramella-Roman

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

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    Systolic and diastolic blood pressure values can be used as an indicator of an individual's risk for cardiovascular disease. The common practice of blood pressure (BP) measurement using a cuff-based system provides a snapshot of blood pressure at a single instance in time and can be inconvenient and intrusive. The development of optical methods to determine blood pressure could provide continuous monitoring of blood pressure through techniques such as pulse transit time (PTT) or pulse arrival time (PAT) when used with echocardiogram. Cuff based BP devices are known to have variation and inaccuracies when applied to larger arm sizes as seen in individuals with obesity but little is known of the influence of obesity in the PPG/PTT and PAT signals. We propose that accurate waveform replication is required for the derivation of blood pressure applied to individuals with obesity. Here we use the Monte Carlo framework to develop the PPG waveform as a means to derive blood pressure through cuff less techniques. The development of a simulated waveform incorporates realistic changes in the artery related to its biomechanical properties as a pressure wave is propagated through the vessel. It is shown that a change in vessel pressure and geometry directly affects the captured optical signal. The system can account for variations in body-mass index to compensate for geometrical changes in adipose tissue layer and changes in optical properties.

    Original languageEnglish
    Title of host publicationProceedings of SPIE
    EditorsBennett L. Ibey, Norbert Linz
    Number of pages9
    PublisherSPIE - International Society for Optical Engineering
    Publication date1 Jan 2020
    Article number112380A
    ISBN (Electronic)9781510632394
    Publication statusPublished - 1 Jan 2020
    EventSPIE Photonics West BiOS: Adaptive Optics and Wavefront Control for Biological Systems VI - The Moscone Center, San Francisco, United States
    Duration: 1 Feb 20206 Feb 2020


    ConferenceSPIE Photonics West BiOS
    LocationThe Moscone Center
    Country/TerritoryUnited States
    CitySan Francisco
    Internet address
    SeriesProgress in Biomedical Optics and Imaging - Proceedings of SPIE


    • Biomechanics
    • Blood Pressure
    • Cardiovascular Disease
    • Monte Carlo
    • Obesity
    • Optical Properties
    • Photon Transport
    • Photoplethysmography


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