Modeling auditory evoked brainstem responses to transient stimuli

Filip Munch Rønne, Torsten Dau, James Harte, Claus Elberling

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Abstract

A quantitative model is presented that describes the formation of auditory brainstem responses (ABR) to tone pulses, clicks and rising chirps
as a function of stimulation level. The model computes the convolution of the instantaneous discharge rates using the “humanized” nonlinear
auditory-nerve (AN) model of Zilany and Bruce (2007) and an empirically derived unitary response function which is assumed to reflect
contributions from different cell populations within the auditory brainstem, recorded at a given pair of electrodes on the scalp. It is shown
that the model accounts for the decrease of tone-pulse evoked wave-V latency with frequency but underestimates the level dependency of
the tone-pulse as well as click-evoked latency values. Furthermore, the model correctly predicts the nonlinear wave-V amplitude behavior in
response to the chirp stimulation both as a function of chirp sweeping rate and level. Overall, the results support the hypothesis that the
pattern of ABR generation is strongly affected by the nonlinear and dispersive processes in the cochlea.
Original languageEnglish
JournalAcoustical Society of America. Journal
Volume131
Issue number5
Pages (from-to)3903-3913
ISSN0001-4966
DOIs
Publication statusPublished - 2012

Keywords

  • Acoustic convolution
  • Acoustic dispersion
  • Auditory evoked potentials
  • Cellular biophysics
  • Nonlinear acoustics

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