Model of Calcium Oscillations Due to Negative Feedback in Olfactory Cilia

Juergen Reidl; Peter Borowski; Anke Sensse; Jens Starke; Martin Zapotocky; Markus Eiswirth

doi:10.1529/biophysj.104.058545

Model of Calcium Oscillations Due to Negative Feedback in Olfactory Cilia

Juergen Reidl, Peter Borowski, Anke Sensse, Jens Starke, Martin Zapotocky, Markus Eiswirth

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We present a mathematical model for Ca oscillations in the cilia of olfactory sensory neurons. The underlying mechanism is based on direct negative regulation of cyclic nucleotide-gated channels by calcium/calmodulin and does not require any autocatalysis such as calcium-induced calcium release. The model is in quantitative agreement with available experimental data, both with respect to oscillations and to fast adaptation. We give predictions for the ranges of parameters in which oscillations should be observable. Relevance of the model to calcium oscillations in other systems is discussed.

Original language	English
Journal	Biophysical Journal
Volume	90
Issue number	4
Pages (from-to)	1147-1155
ISSN	0006-3495
DOIs	https://doi.org/10.1529/biophysj.104.058545
Publication status	Published - 2006

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abstract = "We present a mathematical model for Ca oscillations in the cilia of olfactory sensory neurons. The underlying mechanism is based on direct negative regulation of cyclic nucleotide-gated channels by calcium/calmodulin and does not require any autocatalysis such as calcium-induced calcium release. The model is in quantitative agreement with available experimental data, both with respect to oscillations and to fast adaptation. We give predictions for the ranges of parameters in which oscillations should be observable. Relevance of the model to calcium oscillations in other systems is discussed.",

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AU - Reidl, Juergen

AU - Borowski, Peter

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AU - Starke, Jens

AU - Zapotocky, Martin

AU - Eiswirth, Markus

PY - 2006

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AB - We present a mathematical model for Ca oscillations in the cilia of olfactory sensory neurons. The underlying mechanism is based on direct negative regulation of cyclic nucleotide-gated channels by calcium/calmodulin and does not require any autocatalysis such as calcium-induced calcium release. The model is in quantitative agreement with available experimental data, both with respect to oscillations and to fast adaptation. We give predictions for the ranges of parameters in which oscillations should be observable. Relevance of the model to calcium oscillations in other systems is discussed.

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DO - 10.1529/biophysj.104.058545

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JO - Biophysical Journal

JF - Biophysical Journal

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Model of Calcium Oscillations Due to Negative Feedback in Olfactory Cilia

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