Model of Calcium Oscillations Due to Negative Feedback in Olfactory Cilia

Juergen Reidl, Peter Borowski, Anke Sensse, Jens Starke, Martin Zapotocky, Markus Eiswirth

    Research output: Contribution to journalJournal articleResearchpeer-review


    We present a mathematical model for Ca oscillations in the cilia of olfactory sensory neurons. The underlying mechanism is based on direct negative regulation of cyclic nucleotide-gated channels by calcium/calmodulin and does not require any autocatalysis such as calcium-induced calcium release. The model is in quantitative agreement with available experimental data, both with respect to oscillations and to fast adaptation. We give predictions for the ranges of parameters in which oscillations should be observable. Relevance of the model to calcium oscillations in other systems is discussed.
    Original languageEnglish
    JournalBiophysical Journal
    Issue number4
    Pages (from-to)1147-1155
    Publication statusPublished - 2006


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