Model-based optimization of the primary drying step during freeze-drying

Séverine Thérèse F.C. Mortier, Pieter-Jan Van Bockstal, Ingmar Nopens, Krist V. Gernaey, Thomas De Beer

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

Since large molecules are considered the key driver for growth of the pharmaceutical industry, the focus of the pharmaceutical industry is shifting from small molecules to biopharmaceuticals: around 50% of the approved biopharmaceuticals are freeze-dried products. Therefore, freeze- drying is an important technology to stabilise biopharmaceutical drug products which are unstable in an aqueous solution. However, the freeze-drying process is an energy and time-consuming process. The use of mechanistic modelling to gather process knowledge can assist in optimisation of the process parameters during the operation of the freeze-drying process. By applying a dynamic shelf temperature and chamber pressure, which are the only controllable process variables, the processing time can be decreased by a factor 2 to 3.
Original languageEnglish
Title of host publicationProceedings of the 25th European Symposium on Computer Aided Process Engineering
EditorsKrist V. Gernaey, Jakob K. Huusom, Rafiqul Gani
Volume37
PublisherElsevier
Publication date2015
Pages2177–2182
DOIs
Publication statusPublished - 2015
Event25th European Symposium on Computer Aided Process Engineering : 12th International Symposium on Process Systems Engineering - Copenhagen, Denmark
Duration: 31 May 20154 Jun 2015
http://www.pse2015escape25.dk/

Conference

Conference25th European Symposium on Computer Aided Process Engineering
Country/TerritoryDenmark
CityCopenhagen
Period31/05/201504/06/2015
Internet address
SeriesComputer Aided Chemical Engineering
ISSN1570-7946

Keywords

  • Dynamic Design Space
  • Modelling
  • Optimization
  • Pharmaceuticals

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