Abstract
Since large molecules are considered the key driver for growth of the pharmaceutical industry, the focus of the pharmaceutical industry is shifting from small molecules to biopharmaceuticals: around 50% of the approved biopharmaceuticals are freeze-dried products. Therefore, freeze- drying is an important technology to stabilise biopharmaceutical drug products which are unstable in an aqueous solution. However, the freeze-drying process is an energy and time-consuming process. The use of mechanistic modelling to gather process knowledge can assist in optimisation of the process parameters during the operation of the freeze-drying process. By applying a dynamic shelf temperature and chamber pressure, which are the only controllable process variables, the processing time can be decreased by a factor 2 to 3.
Original language | English |
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Title of host publication | Proceedings of the 25th European Symposium on Computer Aided Process Engineering |
Editors | Krist V. Gernaey, Jakob K. Huusom, Rafiqul Gani |
Volume | 37 |
Publisher | Elsevier |
Publication date | 2015 |
Pages | 2177–2182 |
DOIs | |
Publication status | Published - 2015 |
Event | 25th European Symposium on Computer Aided Process Engineering : 12th International Symposium on Process Systems Engineering - Copenhagen, Denmark Duration: 31 May 2015 → 4 Jun 2015 http://www.pse2015escape25.dk/ |
Conference
Conference | 25th European Symposium on Computer Aided Process Engineering |
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Country/Territory | Denmark |
City | Copenhagen |
Period | 31/05/2015 → 04/06/2015 |
Internet address |
Series | Computer Aided Chemical Engineering |
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ISSN | 1570-7946 |
Keywords
- Dynamic Design Space
- Modelling
- Optimization
- Pharmaceuticals