Mobile On Demand
COVID-19 Vaccine Production Units
for Developing Countries

Steffen Fahr; Samantha Ayde Peña-Benavides; Lukas Thiel; Carl Sengoba; Kaan Karacasulu; Nina Ihling; Juan Eduardo Sosa-Hernández; Gary Gilleskie; John M. Woodley; Roberto Parra-Saldivar; Seyed Soheil Mansouri; Kosan Roh

doi:10.1021/acs.iecr.2c01217

Mobile On Demand COVID-19 Vaccine Production Units for Developing Countries

Steffen Fahr
, Samantha Ayde Peña-Benavides
, Lukas Thiel
, Carl Sengoba
, Kaan Karacasulu
, Nina Ihling
, Juan Eduardo Sosa-Hernández
, Gary Gilleskie
, John M. Woodley
, Roberto Parra-Saldivar^*
, Seyed Soheil Mansouri^*
, Kosan Roh^*

^*Corresponding author for this work

RWTH Aachen University
Technical University of Denmark
Tecnologico de Monterrey
NC State University

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Two years into the COVID-19 pandemic and more than one year after the approval of the first vaccine, bottlenecks in production and supply chain infrastructure continue to delay vaccination campaigns in the Global South. Mobile on Demand (MOD) vaccine manufacture may help quickly ramp up production capacity while bypassing infrastructure bottlenecks. Such decentralized small-scale factories can help tip the scales in the battle against COVID-19 and future pandemics. In this work, we designed two MOD vaccine manufacturing units based on a protein antigen expressed in yeast and in vitro transcription of mRNA. Each unit consists of three shipping containers and can produce on the order of 10,000 vaccine doses daily for competitive prices and in close proximity of their end users. Abandoning economies of scale may lead to a moderate increase in production costs that may be outweighed by reduced closed-vial dose wastage and an earlier protection of vulnerable populations.

Original language	English
Journal	Industrial and Engineering Chemistry Research
Volume	61
Issue number	35
Pages (from-to)	13191–13204
ISSN	0888-5885
DOIs	https://doi.org/10.1021/acs.iecr.2c01217
Publication status	Published - 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1021/acs.iecr.2c01217

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Cite this

Fahr, S., Peña-Benavides, S. A., Thiel, L., Sengoba, C., Karacasulu, K., Ihling, N., Sosa-Hernández, J. E., Gilleskie, G., Woodley, J. M., Parra-Saldivar, R., Mansouri, S. S., & Roh, K. (2022). Mobile On Demand COVID-19 Vaccine Production Units for Developing Countries. Industrial and Engineering Chemistry Research, 61(35), 13191–13204. https://doi.org/10.1021/acs.iecr.2c01217

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title = "Mobile On Demand COVID-19 Vaccine Production Units for Developing Countries",

abstract = "Two years into the COVID-19 pandemic and more than one year after the approval of the first vaccine, bottlenecks in production and supply chain infrastructure continue to delay vaccination campaigns in the Global South. Mobile on Demand (MOD) vaccine manufacture may help quickly ramp up production capacity while bypassing infrastructure bottlenecks. Such decentralized small-scale factories can help tip the scales in the battle against COVID-19 and future pandemics. In this work, we designed two MOD vaccine manufacturing units based on a protein antigen expressed in yeast and in vitro transcription of mRNA. Each unit consists of three shipping containers and can produce on the order of 10,000 vaccine doses daily for competitive prices and in close proximity of their end users. Abandoning economies of scale may lead to a moderate increase in production costs that may be outweighed by reduced closed-vial dose wastage and an earlier protection of vulnerable populations.",

author = "Steffen Fahr and Pe{\~n}a-Benavides, \{Samantha Ayde\} and Lukas Thiel and Carl Sengoba and Kaan Karacasulu and Nina Ihling and Sosa-Hern{\'a}ndez, \{Juan Eduardo\} and Gary Gilleskie and Woodley, \{John M.\} and Roberto Parra-Saldivar and Mansouri, \{Seyed Soheil\} and Kosan Roh",

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doi = "10.1021/acs.iecr.2c01217",

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publisher = "American Chemical Society",

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Fahr, S, Peña-Benavides, SA, Thiel, L, Sengoba, C, Karacasulu, K, Ihling, N, Sosa-Hernández, JE, Gilleskie, G, Woodley, JM, Parra-Saldivar, R, Mansouri, SS & Roh, K 2022, 'Mobile On Demand COVID-19 Vaccine Production Units for Developing Countries', Industrial and Engineering Chemistry Research, vol. 61, no. 35, pp. 13191–13204. https://doi.org/10.1021/acs.iecr.2c01217

TY - JOUR

T1 - Mobile On Demand COVID-19 Vaccine Production Units for Developing Countries

AU - Fahr, Steffen

AU - Peña-Benavides, Samantha Ayde

AU - Thiel, Lukas

AU - Sengoba, Carl

AU - Karacasulu, Kaan

AU - Ihling, Nina

AU - Sosa-Hernández, Juan Eduardo

AU - Gilleskie, Gary

AU - Woodley, John M.

AU - Parra-Saldivar, Roberto

AU - Mansouri, Seyed Soheil

AU - Roh, Kosan

PY - 2022

Y1 - 2022

N2 - Two years into the COVID-19 pandemic and more than one year after the approval of the first vaccine, bottlenecks in production and supply chain infrastructure continue to delay vaccination campaigns in the Global South. Mobile on Demand (MOD) vaccine manufacture may help quickly ramp up production capacity while bypassing infrastructure bottlenecks. Such decentralized small-scale factories can help tip the scales in the battle against COVID-19 and future pandemics. In this work, we designed two MOD vaccine manufacturing units based on a protein antigen expressed in yeast and in vitro transcription of mRNA. Each unit consists of three shipping containers and can produce on the order of 10,000 vaccine doses daily for competitive prices and in close proximity of their end users. Abandoning economies of scale may lead to a moderate increase in production costs that may be outweighed by reduced closed-vial dose wastage and an earlier protection of vulnerable populations.

AB - Two years into the COVID-19 pandemic and more than one year after the approval of the first vaccine, bottlenecks in production and supply chain infrastructure continue to delay vaccination campaigns in the Global South. Mobile on Demand (MOD) vaccine manufacture may help quickly ramp up production capacity while bypassing infrastructure bottlenecks. Such decentralized small-scale factories can help tip the scales in the battle against COVID-19 and future pandemics. In this work, we designed two MOD vaccine manufacturing units based on a protein antigen expressed in yeast and in vitro transcription of mRNA. Each unit consists of three shipping containers and can produce on the order of 10,000 vaccine doses daily for competitive prices and in close proximity of their end users. Abandoning economies of scale may lead to a moderate increase in production costs that may be outweighed by reduced closed-vial dose wastage and an earlier protection of vulnerable populations.

U2 - 10.1021/acs.iecr.2c01217

DO - 10.1021/acs.iecr.2c01217

M3 - Journal article

SN - 0888-5885

VL - 61

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EP - 13204

JO - Industrial and Engineering Chemistry Research

JF - Industrial and Engineering Chemistry Research

IS - 35

ER -