MMPs: From Genomics to Degradomics

Barbara Grünwald*, Pascal Schlage, Achim Krüger, Ulrich Auf Dem Keller

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

This chapter discusses how the drawbacks of a conventional genomics approach led to the misevaluation of matrix metalloproteinases (MMPs) as therapeutic targets. It summarizes recent advancements in our understanding of MMPs as master regulators of tissue homeostasis, and points to specific challenges of using MMPs as therapeutic targets. The chapter introduces the concepts of degradomics-based systems biology and demonstrates how its application to MMP research deepened our understanding of the interconnected activities of members of this protease class within the protease web. The chapter also reviews the results obtained from the genomics approach to MMP function in detail, pointing out valuable information as well as former missing links, those which eventually resulted in the misled predictions and expectations of the effects of therapeutic intervention with MMPs. Global assessment of MMP expression and, more importantly, activity will bring us closer to depicting complete MMP activity degradomes in complex systems.

Original languageEnglish
Title of host publicationMatrix Metalloproteinase Biology
PublisherWiley
Publication date2015
Pages153-181
Chapter9
ISBN (Print)9781118772324
ISBN (Electronic)9781118772287
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Conventional genomics approach
  • Degradomics
  • Matrix metalloproteinases
  • Therapeutic intervention

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