Mixture toxicity of three toxicants with similar and dissimilar modes of action to Daphnia magna

K. Syberg, Anders Elleby Engell-Kofoed, H. Pedersen, N. Cedergreen, V.E. Forbes

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Mixture toxicity of similar- and dissimilar-acting toxicants can be predicted by the models concentration addition (CA) and independent action (IA) using single substance toxicity data. Knowledge of the toxicants mode of action is thus required in order to use the models. In order to test the predictive capability of the models, we conducted Daphnia magna 48 h immobilization experiments with three toxicants with known modes of action (dimethoate, pirimicarb and linear alkyl benzene sulfonate) singly, and in binary and ternary mixtures. Our results indicate that CA and IA predict binary mixtures of similar- and dissimilar-acting toxicants equally well. CA and IA also equally predicted the ternary mixture consisting of both similar- and dissimilar-acting chemicals. The paper discusses the concept of mode of action and the implications the definition of mode of action has on the choice of reference model for mixture toxicity studies.
Original languageEnglish
JournalEcotoxicology and Environmental Safety
Volume69
Issue number3
Pages (from-to)428-436
ISSN0147-6513
DOIs
Publication statusPublished - 2008

Keywords

  • independent action
  • mode of action
  • isobole method
  • mixture toxicity
  • linear alkyl benzene sulfonate
  • pirimicarb
  • concentration addition
  • dimethoate
  • Daphnia magna

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