Mixture Risk Assessment of Complex Real-Life Mixtures—The PANORAMIX Project

Beate I. Escher, Marja Lamoree, Jean-Philippe Antignac, Martin Scholze, Matthias Herzler, Timo Hamers, Tina Kold Jensen, Marc Audebert, Francois Busquet, Dieter Maier, Michael Oelgeschläger, Maria João Valente, Henriette Boye, Sebastian Schmeisser, Gaud Dervilly, Matteo Piumatti, Soléne Motteau, Maria König, Kostja Renko, Maria MargalefRonan Cariou, Yanying Ma, Andreas Frederik Treschow, Andreas Kortenkamp, Anne Marie Vinggaard*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Humans are involuntarily exposed to hundreds of chemicals that either contaminate our environment and food or are added intentionally to our daily products. These complex mixtures of chemicals may pose a risk to human health. One of the goals of the European Union’s Green Deal and zero-pollution ambition for a toxic-free environment is to tackle the existent gaps in chemical mixture risk assessment by providing scientific grounds that support the implementation of adequate regulatory measures within the EU. We suggest dealing with this challenge by: (1) characterising ‘real-life’ chemical mixtures and determining to what extent they are transferred from the environment to humans via food and water, and from the mother to the foetus; (2) establishing a high-throughput whole-mixture-based in vitro strategy for screening of real-life complex mixtures of organic chemicals extracted from humans using integrated chemical profiling (suspect screening) together with effect-directed analysis; (3) evaluating which human blood levels of chemical mixtures might be of concern for children’s development; and (4) developing a web-based, ready-to-use interface that integrates hazard and exposure data to enable component-based mixture risk estimation. These concepts form the basis of the Green Deal project PANORAMIX, whose ultimate goal is to progress mixture risk assessment of chemicals.
Original languageEnglish
Article number12990
JournalInternational Journal of Environmental Research and Public Health
Volume19
Issue number20
Number of pages14
ISSN1661-7827
DOIs
Publication statusPublished - 2022

Keywords

  • Mixture risk assessment
  • Real-life mixtures
  • Developmental neurotoxicity
  • Reproductive toxicity
  • Newmethodological approaches
  • Effect-directed analysis
  • Effect-based trigger values
  • PANORAMIX

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