Mixing signals

Molecular turn ons and turn offs for innate gamma delta T-cells

Vasileios Bekiaris, John R. Sedy, Carl F. Ware

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Lymphocytes of the gamma delta (gamma delta)-cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors, a large proportion respond as innate effectors. gamma delta T-cells are poised to combat infection by responding rapidly to cytokine stimuli similar to innate lymphoid cells. This potential to initiate strong inflammatory responses necessitates that inhibitory signals are balanced with activation signals. Here, we discuss some of the key mechanisms that regulate the development, activation, and inhibition of innate gamma delta T-cells in light of recent evidence that the inhibitory immunoglobulin-superfamily member B and T lymphocyte attenuator restricts their differentiation and effector function.
Original languageEnglish
JournalFrontiers in Immunology
Volume5
Pages (from-to)654
Number of pages1
ISSN1664-3224
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • BTLA
  • IL-7
  • RORγt
  • Dermatitis
  • Lymphotoxin
  • γδ T-cell

Cite this

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title = "Mixing signals: Molecular turn ons and turn offs for innate gamma delta T-cells",
abstract = "Lymphocytes of the gamma delta (gamma delta)-cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors, a large proportion respond as innate effectors. gamma delta T-cells are poised to combat infection by responding rapidly to cytokine stimuli similar to innate lymphoid cells. This potential to initiate strong inflammatory responses necessitates that inhibitory signals are balanced with activation signals. Here, we discuss some of the key mechanisms that regulate the development, activation, and inhibition of innate gamma delta T-cells in light of recent evidence that the inhibitory immunoglobulin-superfamily member B and T lymphocyte attenuator restricts their differentiation and effector function.",
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Mixing signals : Molecular turn ons and turn offs for innate gamma delta T-cells. / Bekiaris, Vasileios; Sedy, John R.; Ware, Carl F.

In: Frontiers in Immunology, Vol. 5, 2014, p. 654.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Mixing signals

T2 - Molecular turn ons and turn offs for innate gamma delta T-cells

AU - Bekiaris, Vasileios

AU - Sedy, John R.

AU - Ware, Carl F.

PY - 2014

Y1 - 2014

N2 - Lymphocytes of the gamma delta (gamma delta)-cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors, a large proportion respond as innate effectors. gamma delta T-cells are poised to combat infection by responding rapidly to cytokine stimuli similar to innate lymphoid cells. This potential to initiate strong inflammatory responses necessitates that inhibitory signals are balanced with activation signals. Here, we discuss some of the key mechanisms that regulate the development, activation, and inhibition of innate gamma delta T-cells in light of recent evidence that the inhibitory immunoglobulin-superfamily member B and T lymphocyte attenuator restricts their differentiation and effector function.

AB - Lymphocytes of the gamma delta (gamma delta)-cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors, a large proportion respond as innate effectors. gamma delta T-cells are poised to combat infection by responding rapidly to cytokine stimuli similar to innate lymphoid cells. This potential to initiate strong inflammatory responses necessitates that inhibitory signals are balanced with activation signals. Here, we discuss some of the key mechanisms that regulate the development, activation, and inhibition of innate gamma delta T-cells in light of recent evidence that the inhibitory immunoglobulin-superfamily member B and T lymphocyte attenuator restricts their differentiation and effector function.

KW - BTLA

KW - IL-7

KW - RORγt

KW - Dermatitis

KW - Lymphotoxin

KW - γδ T-cell

U2 - 10.3389/fimmu.2014.00654

DO - 10.3389/fimmu.2014.00654

M3 - Journal article

VL - 5

SP - 654

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

ER -