Mixed function oxidase dependent biotransformation of polychlorinated biphenyls by different species of fish from the North Sea

G. Mehrtens; F. Laturnus

doi:10.1016/S0045-6535(98)00501-3

Mixed function oxidase dependent biotransformation of polychlorinated biphenyls by different species of fish from the North Sea

G. Mehrtens, F. Laturnus

Research output: Contribution to journal › Journal article › Research

Abstract

Mixed function oxidase (MFO) dependent biotransformation of polychlorinated biphenyls (PCBs) was measured in three different fish species from the North Sea. Liver microsomes of plaice (Pleuronectes platessa), dab (Limanda limanda) and cod (Gadus morhua) were isolated and incubated with different PCB congeners. Metabolites of PCBs were identified as monohydroxylated PCBs. Hydroxylation took place in meta- or para-position of the PCB molecules, preferential in para-position. Metabolization and metabolic rates depended on the substitution pattern of PCBs and the degree of chlorination. Biotransformations were also species dependent. The flatfish dab and plaice exhibited higher metabolic rates than cod (C) 1999 Elsevier Science Ltd. All rights reserved.

Original language	English
Journal	Chemosphere
Volume	38
Issue number	13
Pages (from-to)	2995-3002
ISSN	0045-6535
DOIs	https://doi.org/10.1016/S0045-6535(98)00501-3
Publication status	Published - 1999

Access to Document

10.1016/S0045-6535(98)00501-3

OpenUrl availability

Full text

Cite this

@article{69b3f6a20b1f4feeb3fd7a53c61a582c,

title = "Mixed function oxidase dependent biotransformation of polychlorinated biphenyls by different species of fish from the North Sea",

abstract = "Mixed function oxidase (MFO) dependent biotransformation of polychlorinated biphenyls (PCBs) was measured in three different fish species from the North Sea. Liver microsomes of plaice (Pleuronectes platessa), dab (Limanda limanda) and cod (Gadus morhua) were isolated and incubated with different PCB congeners. Metabolites of PCBs were identified as monohydroxylated PCBs. Hydroxylation took place in meta- or para-position of the PCB molecules, preferential in para-position. Metabolization and metabolic rates depended on the substitution pattern of PCBs and the degree of chlorination. Biotransformations were also species dependent. The flatfish dab and plaice exhibited higher metabolic rates than cod (C) 1999 Elsevier Science Ltd. All rights reserved. ",

keywords = "Planteproduktion og stofoms{\ae}tning",

author = "G. Mehrtens and F. Laturnus",

year = "1999",

doi = "10.1016/S0045-6535(98)00501-3",

language = "English",

volume = "38",

pages = "2995--3002",

journal = "Chemosphere",

issn = "0045-6535",

publisher = "Pergamon Press",

number = "13",

}

TY - JOUR

T1 - Mixed function oxidase dependent biotransformation of polychlorinated biphenyls by different species of fish from the North Sea

AU - Mehrtens, G.

AU - Laturnus, F.

PY - 1999

Y1 - 1999

N2 - Mixed function oxidase (MFO) dependent biotransformation of polychlorinated biphenyls (PCBs) was measured in three different fish species from the North Sea. Liver microsomes of plaice (Pleuronectes platessa), dab (Limanda limanda) and cod (Gadus morhua) were isolated and incubated with different PCB congeners. Metabolites of PCBs were identified as monohydroxylated PCBs. Hydroxylation took place in meta- or para-position of the PCB molecules, preferential in para-position. Metabolization and metabolic rates depended on the substitution pattern of PCBs and the degree of chlorination. Biotransformations were also species dependent. The flatfish dab and plaice exhibited higher metabolic rates than cod (C) 1999 Elsevier Science Ltd. All rights reserved.

AB - Mixed function oxidase (MFO) dependent biotransformation of polychlorinated biphenyls (PCBs) was measured in three different fish species from the North Sea. Liver microsomes of plaice (Pleuronectes platessa), dab (Limanda limanda) and cod (Gadus morhua) were isolated and incubated with different PCB congeners. Metabolites of PCBs were identified as monohydroxylated PCBs. Hydroxylation took place in meta- or para-position of the PCB molecules, preferential in para-position. Metabolization and metabolic rates depended on the substitution pattern of PCBs and the degree of chlorination. Biotransformations were also species dependent. The flatfish dab and plaice exhibited higher metabolic rates than cod (C) 1999 Elsevier Science Ltd. All rights reserved.

KW - Planteproduktion og stofomsætning

U2 - 10.1016/S0045-6535(98)00501-3

DO - 10.1016/S0045-6535(98)00501-3

M3 - Journal article

SN - 0045-6535

VL - 38

SP - 2995

EP - 3002

JO - Chemosphere

JF - Chemosphere

IS - 13

ER -

Mixed function oxidase dependent biotransformation of polychlorinated biphenyls by different species of fish from the North Sea

Abstract

Access to Document

OpenUrl availability

Fingerprint

Cite this