Mixed function oxidase dependent biotransformation of polychlorinated biphenyls by different species of fish from the North Sea

G. Mehrtens, F. Laturnus

    Research output: Contribution to journalJournal articleResearch

    Abstract

    Mixed function oxidase (MFO) dependent biotransformation of polychlorinated biphenyls (PCBs) was measured in three different fish species from the North Sea. Liver microsomes of plaice (Pleuronectes platessa), dab (Limanda limanda) and cod (Gadus morhua) were isolated and incubated with different PCB congeners. Metabolites of PCBs were identified as monohydroxylated PCBs. Hydroxylation took place in meta- or para-position of the PCB molecules, preferential in para-position. Metabolization and metabolic rates depended on the substitution pattern of PCBs and the degree of chlorination. Biotransformations were also species dependent. The flatfish dab and plaice exhibited higher metabolic rates than cod (C) 1999 Elsevier Science Ltd. All rights reserved.
    Original languageEnglish
    JournalChemosphere
    Volume38
    Issue number13
    Pages (from-to)2995-3002
    ISSN0045-6535
    DOIs
    Publication statusPublished - 1999

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