Minor iridoids from Scutellaria albida ssp albida. Inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity of iridoids from Scutellaria sp

Chrysoula Gousiadou, Charlotte Held Gotfredsen, Marina Matsa, Dimitra Hadjipavlou-Litina, Helen Skaltsa

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A new iridoid glycoside, 6'-O-E-caffeoyl-mussaenosidic acid, in addition to one known aglycon, four known triterpenes and one known flavonoid, were isolated from the aerial parts of Scutellaria albida subsp. albida. Furthermore, 12 iridoids with similar structures isolated from Scutellariasp., were examined for their inhibitory potency on lipoxygenase and lipid peroxidation, as well as their antioxidant activity, in comparison to known antioxidants e. g. caffeic acid, nordihydroguaretic acid (NDGA) and trolox. AAPH, DPPH and soybean lipoxygenase (LOX) assays were used for the tests. This investigation led to interesting observations considering the Structure-Activity Relationship. According to our results, the presence of a p-coumaroyl group optimized and even dramatically changed the biological responses of the investigated iridoids
Original languageEnglish
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume28
Issue number4
Pages (from-to)704-710
ISSN1475-6366
DOIs
Publication statusPublished - 2013

Keywords

  • SARs
  • Bioactivity
  • Inhibition
  • Albidoside

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