Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions

Bálint Mészáros, András Hatos, Nicolas Palopoli, Federica Quaglia, Edoardo Salladini, Kim Van Roey, Haribabu Arthanari, Zsuzsanna Dosztányi, Isabella C. Felli, Patrick D. Fischer, Jeffrey C. Hoch, Cy M. Jeffries, Sonia Longhi, Emiliano Maiani, Sandra Orchard, Rita Pancsa, Elena Papaleo, Roberta Pierattelli, Damiano Piovesan, Iva PritisanacLuiggi Tenorio, Thibault Viennet, Peter Tompa, Wim Vranken, Silvio C.E. Tosatto, Norman E. Davey*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


An unambiguous description of an experiment, and the subsequent biological observation, is vital for accurate data interpretation. Minimum information guidelines define the fundamental complement of data that can support an unambiguous conclusion based on experimental observations. We present the Minimum Information About Disorder Experiments (MIADE) guidelines to define the parameters required for the wider scientific community to understand the findings of an experiment studying the structural properties of intrinsically disordered regions (IDRs). MIADE guidelines provide recommendations for data producers to describe the results of their experiments at source, for curators to annotate experimental data to community resources and for database developers maintaining community resources to disseminate the data. The MIADE guidelines will improve the interpretability of experimental results for data consumers, facilitate direct data submission, simplify data curation, improve data exchange among repositories and standardize the dissemination of the key metadata on an IDR experiment by IDR data sources.

Original languageEnglish
JournalNature Methods
Issue number9
Pages (from-to)1291-1303
Publication statusPublished - 2023


Dive into the research topics of 'Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions'. Together they form a unique fingerprint.

Cite this