Miniature ultrasound ring array transducers for transcranial ultrasound neuromodulation of freely-moving small animals

Hyunggug Kim, Seongyeon Kim, Nam Suk Sim, Cristina Pasquinelli, Axel Thielscher, Jeong Ho Lee, Hyunjoo J. Lee*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Background: Current transcranial ultrasound stimulation for small animal in vivo experiment is limited to acute stimulation under anesthesia in stereotaxic fixation due to bulky and heavy curved transducers. Methods: We developed a miniaturized ultrasound ring array transducer which is capable of invoking motor responses through neuromodulation of freely-moving awake mice. Results:: The developed transducer is a 32-element, 183-kHz ring array with a weight of 0.035 g (with PCB: 0.73 g), a diameter of 8.1 mm, a focal length of 2.3 mm, and lateral resolution of 2.75 mm. By developing an affixation scheme suitable for freely-moving animals, the transducer was successfully coupled to the mouse brain and induced motor responses in both affixed and awake states. Conclusion: Ultrasound neuromodulation of a freely-moving animal is now possible using the developed lightweight and compact system to conduct a versatile set of in vivo experiments.
Original languageEnglish
JournalBrain Stimulation
Volume12
Issue number2
Pages (from-to)251-255
ISSN1935-861X
DOIs
Publication statusPublished - 2018

Keywords

  • LIPUS
  • Ultrasound transducer
  • Freely-moving
  • Neuromodulation

Cite this

Kim, Hyunggug ; Kim, Seongyeon ; Sim, Nam Suk ; Pasquinelli, Cristina ; Thielscher, Axel ; Lee, Jeong Ho ; Lee, Hyunjoo J. / Miniature ultrasound ring array transducers for transcranial ultrasound neuromodulation of freely-moving small animals. In: Brain Stimulation. 2018 ; Vol. 12, No. 2. pp. 251-255.
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abstract = "Background: Current transcranial ultrasound stimulation for small animal in vivo experiment is limited to acute stimulation under anesthesia in stereotaxic fixation due to bulky and heavy curved transducers. Methods: We developed a miniaturized ultrasound ring array transducer which is capable of invoking motor responses through neuromodulation of freely-moving awake mice. Results:: The developed transducer is a 32-element, 183-kHz ring array with a weight of 0.035 g (with PCB: 0.73 g), a diameter of 8.1 mm, a focal length of 2.3 mm, and lateral resolution of 2.75 mm. By developing an affixation scheme suitable for freely-moving animals, the transducer was successfully coupled to the mouse brain and induced motor responses in both affixed and awake states. Conclusion: Ultrasound neuromodulation of a freely-moving animal is now possible using the developed lightweight and compact system to conduct a versatile set of in vivo experiments.",
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author = "Hyunggug Kim and Seongyeon Kim and Sim, {Nam Suk} and Cristina Pasquinelli and Axel Thielscher and Lee, {Jeong Ho} and Lee, {Hyunjoo J.}",
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Miniature ultrasound ring array transducers for transcranial ultrasound neuromodulation of freely-moving small animals. / Kim, Hyunggug ; Kim, Seongyeon; Sim, Nam Suk; Pasquinelli, Cristina; Thielscher, Axel; Lee, Jeong Ho; Lee, Hyunjoo J.

In: Brain Stimulation, Vol. 12, No. 2, 2018, p. 251-255.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Miniature ultrasound ring array transducers for transcranial ultrasound neuromodulation of freely-moving small animals

AU - Kim, Hyunggug

AU - Kim, Seongyeon

AU - Sim, Nam Suk

AU - Pasquinelli, Cristina

AU - Thielscher, Axel

AU - Lee, Jeong Ho

AU - Lee, Hyunjoo J.

PY - 2018

Y1 - 2018

N2 - Background: Current transcranial ultrasound stimulation for small animal in vivo experiment is limited to acute stimulation under anesthesia in stereotaxic fixation due to bulky and heavy curved transducers. Methods: We developed a miniaturized ultrasound ring array transducer which is capable of invoking motor responses through neuromodulation of freely-moving awake mice. Results:: The developed transducer is a 32-element, 183-kHz ring array with a weight of 0.035 g (with PCB: 0.73 g), a diameter of 8.1 mm, a focal length of 2.3 mm, and lateral resolution of 2.75 mm. By developing an affixation scheme suitable for freely-moving animals, the transducer was successfully coupled to the mouse brain and induced motor responses in both affixed and awake states. Conclusion: Ultrasound neuromodulation of a freely-moving animal is now possible using the developed lightweight and compact system to conduct a versatile set of in vivo experiments.

AB - Background: Current transcranial ultrasound stimulation for small animal in vivo experiment is limited to acute stimulation under anesthesia in stereotaxic fixation due to bulky and heavy curved transducers. Methods: We developed a miniaturized ultrasound ring array transducer which is capable of invoking motor responses through neuromodulation of freely-moving awake mice. Results:: The developed transducer is a 32-element, 183-kHz ring array with a weight of 0.035 g (with PCB: 0.73 g), a diameter of 8.1 mm, a focal length of 2.3 mm, and lateral resolution of 2.75 mm. By developing an affixation scheme suitable for freely-moving animals, the transducer was successfully coupled to the mouse brain and induced motor responses in both affixed and awake states. Conclusion: Ultrasound neuromodulation of a freely-moving animal is now possible using the developed lightweight and compact system to conduct a versatile set of in vivo experiments.

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KW - Ultrasound transducer

KW - Freely-moving

KW - Neuromodulation

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