Migration of cells in a social context

Søren Vedel, Savas Tay, Darius M Johnston, Henrik Bruus, Stephen R Quake

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In multicellular organisms and complex ecosystems, cells migrate in a social context. Whereas this is essential for the basic processes of life, the influence of neighboring cells on the individual remains poorly understood. Previous work on isolated cells has observed a stereotypical migratory behavior characterized by short-time directional persistence with long-time random movement. We discovered a much richer dynamic in the social context, with significant variations in directionality, displacement, and speed, which are all modulated by local cell density. We developed a mathematical model based on the experimentally identified "cellular traffic rules" and basic physics that revealed that these emergent behaviors are caused by the interplay of single-cell properties and intercellular interactions, the latter being dominated by a pseudopod formation bias mediated by secreted chemicals and pseudopod collapse following collisions. The model demonstrates how aspects of complex biology can be explained by simple rules of physics and constitutes a rapid test bed for future studies of collective migration of individual cells.
Original languageEnglish
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number1
Pages (from-to)129-134
ISSN0027-8424
DOIs
Publication statusPublished - 2013

Keywords

  • Cell Migration
  • Single-Cell Analysis
  • Physical Modeling
  • Microfluidics

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