Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber

Christian Rosenberg Petersen; Nikola Prtljaga; Mark Farries; Jon Ward; Bruce Napier; Gavin Rhys Lloyd; Jayakrupakar Nallala; Nick Stone; Ole Bang

doi:10.1117/12.2288541

Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber

Christian Rosenberg Petersen (Invited author)
, Nikola Prtljaga (Invited author)
, Mark Farries (Invited author)
, Jon Ward (Invited author)
, Bruce Napier (Invited author)
, Gavin Rhys Lloyd (Invited author)
, Jayakrupakar Nallala (Invited author)
, Nick Stone (Invited author)
, Ole Bang (Invited author)

Gooch and Housego Ltd.
Vivid Components Ltd.
University of Gloucestershire
University of Exeter

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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Abstract

We present the first demonstration of mid-infrared spectroscopic imaging of human tissue using a fiber-coupled supercontinuum source spanning from 2-7.5 μm. The supercontinuum was generated in a tapered large mode area chalcogenide photonic crystal fiber in order to obtain broad bandwidth, high average power, and single-mode output for good imaging properties. Tissue imaging was demonstrated in transmission by raster scanning over a sub-mm region of paraffinized colon tissue on CaF2 substrate, and the signal was measured using a fiber-coupled grating spectrometer. This demonstration has shown that we can distinguish between epithelial and surrounding connective tissues within a paraffinized section of colon tissue by imaging at discrete wavelengths related to distinct chemical absorption features.

Original language	English
Title of host publication	Proceedings of SPIE
Number of pages	6
Volume	10489
Publisher	SPIE - International Society for Optical Engineering
Publication date	2018
Article number	1048905
DOIs	https://doi.org/10.1117/12.2288541
Publication status	Published - 2018
Event	SPIE Photonics West BiOS 2018 - Moscone Center, San Francisco, United States Duration: 27 Jan 2018 → 1 Feb 2018 https://spie.org/PWB/conferencedetails/multiphoton-microscopy

Conference

Conference	SPIE Photonics West BiOS 2018
Location	Moscone Center
Country/Territory	United States
City	San Francisco
Period	27/01/2018 → 01/02/2018
Internet address	https://spie.org/PWB/conferencedetails/multiphoton-microscopy

Series	Proceedings of SPIE - The International Society for Optical Engineering
ISSN	0277-786X

Keywords

Supercontinuum
Spectroscopic imaging
Mid-infrared
Tissue imaging
Chalcogenide optical fibers

Access to Document

10.1117/12.2288541

1048905Final published version, 4.54 MB

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Petersen, C. R., Prtljaga, N., Farries, M., Ward, J., Napier, B., Lloyd, G. R., Nallala, J., Stone, N., & Bang, O. (2018). Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber. In Proceedings of SPIE (Vol. 10489). Article 1048905 SPIE - International Society for Optical Engineering. https://doi.org/10.1117/12.2288541

@inproceedings{e878ba69e18449e084a748b5c2ebae41,

title = "Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber",

abstract = "We present the first demonstration of mid-infrared spectroscopic imaging of human tissue using a fiber-coupled supercontinuum source spanning from 2-7.5 μm. The supercontinuum was generated in a tapered large mode area chalcogenide photonic crystal fiber in order to obtain broad bandwidth, high average power, and single-mode output for good imaging properties. Tissue imaging was demonstrated in transmission by raster scanning over a sub-mm region of paraffinized colon tissue on CaF2 substrate, and the signal was measured using a fiber-coupled grating spectrometer. This demonstration has shown that we can distinguish between epithelial and surrounding connective tissues within a paraffinized section of colon tissue by imaging at discrete wavelengths related to distinct chemical absorption features.",

keywords = "Supercontinuum, Spectroscopic imaging, Mid-infrared, Tissue imaging, Chalcogenide optical fibers",

author = "Petersen, \{Christian Rosenberg\} and Nikola Prtljaga and Mark Farries and Jon Ward and Bruce Napier and Lloyd, \{Gavin Rhys\} and Jayakrupakar Nallala and Nick Stone and Ole Bang",

year = "2018",

doi = "10.1117/12.2288541",

language = "English",

volume = "10489",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "SPIE - International Society for Optical Engineering",

booktitle = "Proceedings of SPIE",

note = "SPIE Photonics West BiOS 2018 ; Conference date: 27-01-2018 Through 01-02-2018",

url = "https://spie.org/PWB/conferencedetails/multiphoton-microscopy",

}

Petersen, CR, Prtljaga, N, Farries, M, Ward, J, Napier, B, Lloyd, GR, Nallala, J, Stone, N & Bang, O 2018, Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber. in Proceedings of SPIE. vol. 10489, 1048905, SPIE - International Society for Optical Engineering, Proceedings of SPIE - The International Society for Optical Engineering, SPIE Photonics West BiOS 2018, San Francisco, California, United States, 27/01/2018. https://doi.org/10.1117/12.2288541

Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber. / Petersen, Christian Rosenberg (Invited author); Prtljaga, Nikola (Invited author); Farries, Mark (Invited author) et al.
Proceedings of SPIE. Vol. 10489 SPIE - International Society for Optical Engineering, 2018. 1048905 (Proceedings of SPIE - The International Society for Optical Engineering).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

TY - GEN

T1 - Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber

AU - Petersen, Christian Rosenberg

AU - Prtljaga, Nikola

AU - Farries, Mark

AU - Ward, Jon

AU - Napier, Bruce

AU - Lloyd, Gavin Rhys

AU - Nallala, Jayakrupakar

AU - Stone, Nick

AU - Bang, Ole

PY - 2018

Y1 - 2018

N2 - We present the first demonstration of mid-infrared spectroscopic imaging of human tissue using a fiber-coupled supercontinuum source spanning from 2-7.5 μm. The supercontinuum was generated in a tapered large mode area chalcogenide photonic crystal fiber in order to obtain broad bandwidth, high average power, and single-mode output for good imaging properties. Tissue imaging was demonstrated in transmission by raster scanning over a sub-mm region of paraffinized colon tissue on CaF2 substrate, and the signal was measured using a fiber-coupled grating spectrometer. This demonstration has shown that we can distinguish between epithelial and surrounding connective tissues within a paraffinized section of colon tissue by imaging at discrete wavelengths related to distinct chemical absorption features.

AB - We present the first demonstration of mid-infrared spectroscopic imaging of human tissue using a fiber-coupled supercontinuum source spanning from 2-7.5 μm. The supercontinuum was generated in a tapered large mode area chalcogenide photonic crystal fiber in order to obtain broad bandwidth, high average power, and single-mode output for good imaging properties. Tissue imaging was demonstrated in transmission by raster scanning over a sub-mm region of paraffinized colon tissue on CaF2 substrate, and the signal was measured using a fiber-coupled grating spectrometer. This demonstration has shown that we can distinguish between epithelial and surrounding connective tissues within a paraffinized section of colon tissue by imaging at discrete wavelengths related to distinct chemical absorption features.

KW - Supercontinuum

KW - Spectroscopic imaging

KW - Mid-infrared

KW - Tissue imaging

KW - Chalcogenide optical fibers

U2 - 10.1117/12.2288541

DO - 10.1117/12.2288541

M3 - Article in proceedings

VL - 10489

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Proceedings of SPIE

PB - SPIE - International Society for Optical Engineering

T2 - SPIE Photonics West BiOS 2018

Y2 - 27 January 2018 through 1 February 2018

ER -

Petersen CR, Prtljaga N, Farries M, Ward J, Napier B, Lloyd GR et al. Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber. In Proceedings of SPIE. Vol. 10489. SPIE - International Society for Optical Engineering. 2018. 1048905. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.2288541

Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber

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Keywords

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