Microwave assisted click chemistry on a conductive polymer film

Anders Egede Daugaard, Thomas S. Hansen, Niels Bent Larsen, Søren Hvilsted

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Microwave (MW) irradiation has been used to accelerate the functionalization of an azide functional poly(3,4-ethylenedioxythiophene) film by click chemistry. The absorption of MW energy by the conductive polymer has been exploited for localized activation of the reaction on the polymer surface. By use of an alkyne modified fluorescein derivative the reaction conditions have been optimized in a conventional MW oven, enabling the use of different sizes of substrates. The optimization resulted in a reduction of reaction times of approximately 20h to only 2min for bulk film functionalization. The method has been applied for anchoring of the chelating agent nitrilotriacetic acid (NTA) on the conductive polymer. The chelating linkage ability of NTA on the surface was investigated through a sandwich ELISA study confirming the selective bonding of a histidine tagged protein.
Original languageEnglish
JournalSynthetic Metals
Volume161
Issue number9-10
Pages (from-to)812-816
ISSN0379-6779
DOIs
Publication statusPublished - 2011

Keywords

  • Conductive polymers
  • Nitrilotriacetic acid (NTA)
  • Poly(3,4-ethylenedioxythiophene) (PEDOT)
  • Microwave reaction
  • Click chemistry

Cite this

Daugaard, Anders Egede ; Hansen, Thomas S. ; Larsen, Niels Bent ; Hvilsted, Søren. / Microwave assisted click chemistry on a conductive polymer film. In: Synthetic Metals. 2011 ; Vol. 161, No. 9-10. pp. 812-816.
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Microwave assisted click chemistry on a conductive polymer film. / Daugaard, Anders Egede; Hansen, Thomas S.; Larsen, Niels Bent; Hvilsted, Søren.

In: Synthetic Metals, Vol. 161, No. 9-10, 2011, p. 812-816.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Microwave assisted click chemistry on a conductive polymer film

AU - Daugaard, Anders Egede

AU - Hansen, Thomas S.

AU - Larsen, Niels Bent

AU - Hvilsted, Søren

PY - 2011

Y1 - 2011

N2 - Microwave (MW) irradiation has been used to accelerate the functionalization of an azide functional poly(3,4-ethylenedioxythiophene) film by click chemistry. The absorption of MW energy by the conductive polymer has been exploited for localized activation of the reaction on the polymer surface. By use of an alkyne modified fluorescein derivative the reaction conditions have been optimized in a conventional MW oven, enabling the use of different sizes of substrates. The optimization resulted in a reduction of reaction times of approximately 20h to only 2min for bulk film functionalization. The method has been applied for anchoring of the chelating agent nitrilotriacetic acid (NTA) on the conductive polymer. The chelating linkage ability of NTA on the surface was investigated through a sandwich ELISA study confirming the selective bonding of a histidine tagged protein.

AB - Microwave (MW) irradiation has been used to accelerate the functionalization of an azide functional poly(3,4-ethylenedioxythiophene) film by click chemistry. The absorption of MW energy by the conductive polymer has been exploited for localized activation of the reaction on the polymer surface. By use of an alkyne modified fluorescein derivative the reaction conditions have been optimized in a conventional MW oven, enabling the use of different sizes of substrates. The optimization resulted in a reduction of reaction times of approximately 20h to only 2min for bulk film functionalization. The method has been applied for anchoring of the chelating agent nitrilotriacetic acid (NTA) on the conductive polymer. The chelating linkage ability of NTA on the surface was investigated through a sandwich ELISA study confirming the selective bonding of a histidine tagged protein.

KW - Conductive polymers

KW - Nitrilotriacetic acid (NTA)

KW - Poly(3,4-ethylenedioxythiophene) (PEDOT)

KW - Microwave reaction

KW - Click chemistry

U2 - 10.1016/j.synthmet.2011.02.005

DO - 10.1016/j.synthmet.2011.02.005

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JO - Synthetic Metals

JF - Synthetic Metals

SN - 0379-6779

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ER -